58611-62-4Relevant academic research and scientific papers
Inhibitors or bone reabsorption and antagonists of vitronectin receptors
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, (2008/06/13)
Novel inhibitors of bone reabsorption and antagonists of vitronectin receptors The present invention relates to 5-membered ring heterocycles of the formula I, in which E, F, G, W, Y and Z have the meaning given in the patent claims, to their preparation a
Design and Synthesis of &γ-Oxygenated Phosphinothricins as Inhibitors of Glutamine Synthetase
Walker, Daniel M.,McDonald, John F.,Franz, John E.,Logusch, Eugene W.
, p. 659 - 666 (2007/10/02)
The ability of L-γ-hydroxyglutamic acids to act as substrates of the enzyme glutamine synthetase (GS) was exploited as a rationale for the synthesis of γ-oxygenated analogues of the naturally occurring GS inhibitor phosphinothricin (PPT).The potent new in
Synthesis of D,L-&γ-Hydroxyphosphinothricin, a Potent New Inhibitor of Glutamine Synthetase
Walker, Daniel M.,McDonald, John F.,Logusch, Eugene W.
, p. 1710 - 1711 (2007/10/02)
A flexible synthesis of D,L-γ-hydroxyphosphothricin (GHPPT), a potent inhibitor of the enzyme glutamine synthetase, is described which features silicon-mediated addition of ethyl methylphosphinate to benzyl 2-benzyloxycarbonylamino-4-oxobutyrate; selectiv
Synthesis of (Z)-4-(acylamino)- and 4-(alkylamino)-α-oximinophenylacetic acids: properties and stereochemical determination
Domagala, John M.,Haskell, Theodore H.
, p. 134 - 140 (2007/10/02)
The preparation, properties, and stereochemical determinations of a series of 4-substituted α-oximinophenylacetic acids are described.The 4-acetamino and 4-amino>-α-oxophenylacetic acids 7 and 19 were synthesized from the corresponding acetophenones with selenium dioxide.The oximes were then prepared and their stereochemistry determined as Z (syn), through the chemical properties of the methoxyimino derivatives.A key intermediate was (Z)-methyl 4-amino>-α-imino>phenylacetate (24), which was synthesized from the free oxime or from the keto acid by using O-(tetrahydropyran-2-yl)hydroxylamine.Deprotection of this compound at nitrogen gave the 4-amino-α-oximino ester, 25, which was acylated with a variety of acid chlorides and hydrolyzed to the 4-(acylamino)-α-oximinophenylacetic acids.By employment of methyl 4-amino-α-oxophenylacetate dimethyl ketal (9), a general reductive amination process was developed, leading to the 4-(alkylamino)-α-oximinophenylacetic acids.
Analogues of S adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5' thioether linkage
Chang,Coward
, p. 684 - 691 (2007/10/06)
The synthesis of S adenosylhomocysteine analogues, in which the 5' thioether linkage is replaced by an oxygen or nitrogen isostere, has been investigated. These compounds were designed to be resistant to enzyme catalyzed hydrolytic cleavage of the 5' subs
