BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)-

Base Information

• Chemical Name: BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)-
• CAS No.: 1391052-24-6
• Molecular Formula: C₂₀H₂₀Cl₂N₂O₃
• Molecular Weight: 407.296
• Mol file: 1391052-24-6.mol

Synonyms:

Chemical Property of BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)-

Chemical Property:

• Boiling Point: 479.7±45.0 °C(Predicted)
• PKA: 10.13±0.70(Predicted)
• Density: 1.395±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3,4-Di(cyclopropylmethoxy)Roflumilast ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Di(cyclopropylmethoxy) Roflumilast is an impurity of Roflumilast (R639700).

Technology Process of BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)-

There total 4 articles about BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

3,5-dichloro-4-aminopyridine (22889-78-7) + 3,4-bis(cyclopropylmethoxy)benzoyl chloride (669001-67-6) → 3,4-bis(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl) benzamide (1391052-24-6)

Guidance literature:

With sodium hydride; In acetonitrile; at -5 - 0 ℃; for 1h;

DOI:10.3184/174751914X14061300074410

Reference yield:

3,4-dihydroxybenzaldehyde (139-85-5) → 3,4-bis(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl) benzamide (1391052-24-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / Reflux

2: aminosulfonic acid; sodium chlorite / acetonitrile; water / 2 h / 5 - 20 °C

3: thionyl chloride; N,N-dimethyl-formamide / toluene / 3 h / Dean-Stark; Reflux

4: sodium hydride / acetonitrile / 1 h / -5 - 0 °C

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; In water; toluene; acetonitrile;

DOI:10.3184/174751914X14061300074410

Reference yield:

3,4-bis(cyclopropylmethoxy)benzaldehyde (1369817-76-4) → 3,4-bis(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl) benzamide (1391052-24-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aminosulfonic acid; sodium chlorite / acetonitrile; water / 2 h / 5 - 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 3 h / Dean-Stark; Reflux

3: sodium hydride / acetonitrile / 1 h / -5 - 0 °C

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; N,N-dimethyl-formamide; In water; toluene; acetonitrile;

DOI:10.3184/174751914X14061300074410

upstream raw materials:

3,5-dichloro-4-aminopyridine

3,4-bis(cyclopropylmethoxy)benzoyl chloride

3,4-dihydroxybenzaldehyde

3,4-bis(cyclopropylmethoxy)benzaldehyde

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