C₁₈H₁₆N₂O₂

Base Information

• Chemical Name: C₁₈H₁₆N₂O₂
• CAS No.: 1644057-96-4
• Molecular Formula: C₁₈H₁₆N₂O₂
• Molecular Weight: 292.337
• Mol file: 1644057-96-4.mol

Synonyms:

Chemical Property of C₁₈H₁₆N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₆N₂O₂

There total 3 articles about C₁₈H₁₆N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

1-bromo-4-methoxy-benzene (104-92-7) + C23H36N2OSn (1644057-99-7) → 2-benzyloxy-6-phenylpyrazine (1279817-20-7) + C18H16N2O2 (1644057-96-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; lithium chloride; In tetrahydrofuran; at 70 ℃; for 18h;

DOI:10.1055/s-0034-1378331

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 2-benzyloxy-6-phenylpyrazine (1279817-20-7) + C18H16N2O2 (1644057-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / toluene / 50 °C

2: sodium hydride / tetrahydrofuran / -78 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; copper(l) chloride / tetrahydrofuran / 18 h / 70 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; copper(l) chloride; lithium chloride; In tetrahydrofuran; toluene; 3: |Stille Cross Coupling;

DOI:10.1055/s-0034-1378331

Reference yield:

2-(benzyloxy)-6-chloropyrazine (4774-18-9) → 2-benzyloxy-6-phenylpyrazine (1279817-20-7) + C18H16N2O2 (1644057-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / -78 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; copper(l) chloride / tetrahydrofuran / 18 h / 70 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; copper(l) chloride; lithium chloride; In tetrahydrofuran; 2: |Stille Cross Coupling;

DOI:10.1055/s-0034-1378331

upstream raw materials:

benzyl alcohol

2-(benzyloxy)-6-chloropyrazine

1-bromo-4-methoxy-benzene

C₂₃H₃₆N₂OSn