N-benzyl-4-hydroxy-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: N-benzyl-4-hydroxy-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 70273-41-5
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.317
• Mol file: 70273-41-5.mol

Synonyms:

Chemical Property of N-benzyl-4-hydroxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-4-hydroxy-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about N-benzyl-4-hydroxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

(N,N-dibenzyl)aminoacetaldehyde diethyl acetal (67280-28-8) → N-benzyl-4-hydroxy-1,2,3,4-tetrahydroisoquinoline (70273-41-5) + 7,12-dihydro-5H-6,12-methanodibenzazocine (67280-33-5) + 2-N,N-Dibenzylaminoacetaldehyde (106889-84-3) + N-benzyl-4-ethoxy-1,2,3,4-tetrahydroisoquinoline (106889-85-4)

Guidance literature:

With perchloric acid; for 3h; Product distribution; Ambient temperature; depends on the kinds of acid and the acidity and the temperature;

Reference yield: 39.0%

N-benzyl-4-ethoxy-1,2,3,4-tetrahydroisoquinoline (106889-85-4) → N-benzyl-4-hydroxy-1,2,3,4-tetrahydroisoquinoline (70273-41-5) + 7,12-dihydro-5H-6,12-methanodibenzazocine (67280-33-5)

Guidance literature:

With perchloric acid; for 3h; Ambient temperature;

Reference yield:

benzyl chloride (100-44-7) → N-benzyl-4-hydroxy-1,2,3,4-tetrahydroisoquinoline (70273-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / K₂CO₃ / ethanol; H₂O / 6 h / Heating

2: 27 percent / 70percent HClO₄ / 1 h / 0 °C

With perchloric acid; potassium carbonate; In ethanol; water;

upstream raw materials:

(N,N-dibenzyl)aminoacetaldehyde diethyl acetal

N-benzyl-4-ethoxy-1,2,3,4-tetrahydroisoquinoline

benzyl chloride

Downstream raw materials:

6-methyl-12-methylene-5,6,7,12-tetrahydro-dibenzo[c,f]azocine

Refernces