106889-84-3Relevant articles and documents
A Nitrone Dipolar Cycloaddition Strategy toward an Enantioselective Synthesis of Massadine
Cannon, Jeffrey S.
, p. 3883 - 3887 (2018)
An enantioselective route to the C,D-bicycle of massadine is reported. Enantiopure intermediates were generated by a single stereoselective reduction using the Corey-Bakshi-Shibata reagent. This initial stereoinduction was translated into the five contigu
AZACARBAZOLE BTK INHIBITORS
-
, (2016/10/31)
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein CH, R1, R1a, R1b, R2, R3, and the subscripts m1, m2, p, q, and t are as set forth herein. The present invention also provides pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
Towards convenient precursors for α-phosphonylated aziridinium ions
Piotrowska, Dorota G.,Wroblewski, Andrzej E.
experimental part, p. 998 - 1016 (2009/12/03)
Mixtures of the respective 2-(N,N-dibenzylamino)-1-chloro- and 1-(N,N-dibenzylamino)-2-chlorophosphonates were obtained after mesylation of dimethyl (1R,2S)-2-(N,N-dibenzylamino)-1-hydroxy-3-methylbutylphosphonate and diethyl (1R,2S)-2-(N,N-dibenzylamino)-1-hydroxy-3-phenylpropylphosphonate with mesyl chloride in the presence of tetraethylammonium chloride. These mixtures are considered as useful precursors to-phosphonylated aziridinium ions.
