FMOC-4-AMINO-3-METHYLBENZOIC ACID

Base Information

• Chemical Name: FMOC-4-AMINO-3-METHYLBENZOIC ACID
• CAS No.: 892878-63-6
• Molecular Formula: C₂₃H₁₉NO₄
• Molecular Weight: 373.408
• Mol file: 892878-63-6.mol

Synonyms:

Chemical Property of FMOC-4-AMINO-3-METHYLBENZOIC ACID

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Fmoc-4-amino-3-methylbenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FMOC-4-AMINO-3-METHYLBENZOIC ACID

There total 1 articles about FMOC-4-AMINO-3-METHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 4-amino 3-methylbenzoic acid (2486-70-6) → 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbenzoic acid (892878-63-6)

Guidance literature:

In tetrahydrofuran; Inert atmosphere; Reflux;

DOI:10.1002/chem.201204098

Reference yield:

4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbenzoic acid (892878-63-6) → C48H42N6O14S2

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / 5 h / Reflux

2.1: pyridine / acetone / 8 h / 0 - 20 °C

3.1: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

4.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1 h

4.2: 8 h / 20 °C

With pyridine; thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.3390/ijms22115482

Reference yield:

4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbenzoic acid (892878-63-6) → 4-amino-3-methyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 5 h / Reflux

2: pyridine / acetone / 8 h / 0 - 20 °C

3: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

With pyridine; thionyl chloride; diethylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.3390/ijms22115482

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

4-amino 3-methylbenzoic acid

Refernces

• 1、 Murphy, Natasha S.,Prabhakaran, Panchami,Azzarito, Valeria,Plante, Jeffrey P.,Hardie, Michaele J.,Kilner, Colin A.,Warriner, Stuart L.,Wilson, Andrew J.. "Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions". supporting information. p. 5546 - 5550. Retrieved 2013/06/27.