Technology Process of 2-(4-{2-[1-(Tetrahydro-pyran-2-yl)-1H-tetrazol-5-ylmethyl]-benzyloxy}-phenoxymethyl)-quinoline
There total 7 articles about 2-(4-{2-[1-(Tetrahydro-pyran-2-yl)-1H-tetrazol-5-ylmethyl]-benzyloxy}-phenoxymethyl)-quinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 77 percent / NaN3, Et3N*HCl, NMP / 20 h / 120 °C
2: 66 percent / NBS, PPh3 / tetrahydrofuran / 14 h / from 0 deg C to room temp.
3: PPTS / CH2Cl2 / 1 h / Ambient temperature
4: KF*alumina / acetonitrile / 5 h / 50 °C
With
1-methyl-pyrrolidin-2-one; potassium fluoride on basic alumina; N-Bromosuccinimide; sodium azide; pyridinium p-toluenesulfonate; triethylamine hydrochloride; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(96)02460-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 62 percent / NaBH4, I2 / tetrahydrofuran
2: 77 percent / NaN3, Et3N*HCl, NMP / 20 h / 120 °C
3: 66 percent / NBS, PPh3 / tetrahydrofuran / 14 h / from 0 deg C to room temp.
4: PPTS / CH2Cl2 / 1 h / Ambient temperature
5: KF*alumina / acetonitrile / 5 h / 50 °C
With
1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; potassium fluoride on basic alumina; N-Bromosuccinimide; sodium azide; iodine; pyridinium p-toluenesulfonate; triethylamine hydrochloride; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(96)02460-4
- Guidance literature:
-
Multi-step reaction with 2 steps
1: PPTS / CH2Cl2 / 1 h / Ambient temperature
2: KF*alumina / acetonitrile / 5 h / 50 °C
With
potassium fluoride on basic alumina; pyridinium p-toluenesulfonate;
In
dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(96)02460-4