C₂₂H₂₀FN₅O₄

Base Information

Chemical Name:C₂₂H₂₀FN₅O₄
CAS No.:959321-16-5
Molecular Formula:C₂₂H₂₀FN₅O₄
Molecular Weight:437.43
Hs Code.:

C<sub>22</sub>H<sub>20</sub>FN<sub>5</sub>O<sub>4</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₂H₂₀FN₅O₄

Chemical Property:

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Technology Process of C₂₂H₂₀FN₅O₄

There total 8 articles about C₂₂H₂₀FN₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1422029-67-1
2-(4-fluoro-7-(methylcarbamoyl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

: 56227-55-5,79332-89-1
N-benzoylpiperazine hydrochloride

: 959321-16-5
C₂₂H₂₀FN₅O₄

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jm3016377

Reference yield:

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 959321-16-5
C₂₂H₂₀FN₅O₄

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrafluoroboric acid; sodium nitrite / ethanol; water / 3 h / 0 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / toluene / 2 h / Inert atmosphere; Sealed tube; Heating

3.1: sulfuric acid; nitric acid / 1 h / 20 - 80 °C / Inert atmosphere

4.1: tetrahydrofuran / 2.25 h / Inert atmosphere; Cooling

5.1: N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Sealed tube

6.1: sodium hydroxide / ethanol / 18 h / Inert atmosphere; Sealed tube; Heating

6.2: 20 °C / pH 2 / Inert atmosphere; Sealed tube

7.1: 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride / 48 h / 20 °C / Inert atmosphere

8.2: Inert atmosphere; Cooling with ice

9.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; aluminum (III) chloride; tetrafluoroboric acid; sulfuric acid; nitric acid; 4-methylmorpholine N-oxide; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; 4.1: |Bartoli Indole Synthesis;
DOI:10.1021/jm3016377

Reference yield:

: 51173-05-8
5-fluoropyridin-2-ol

: 959321-16-5
C₂₂H₂₀FN₅O₄

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / 1 h / 20 - 80 °C / Inert atmosphere

2.1: tetrahydrofuran / 2.25 h / Inert atmosphere; Cooling

3.1: N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Sealed tube

4.1: sodium hydroxide / ethanol / 18 h / Inert atmosphere; Sealed tube; Heating

4.2: 20 °C / pH 2 / Inert atmosphere; Sealed tube

5.1: 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C / Inert atmosphere

6.1: aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride / 48 h / 20 °C / Inert atmosphere

6.2: Inert atmosphere; Cooling with ice

7.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; aluminum (III) chloride; sulfuric acid; nitric acid; 4-methylmorpholine N-oxide; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 2.1: |Bartoli Indole Synthesis;
DOI:10.1021/jm3016377