(R)-3-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-8-fluoro-5,5-dimethyl-3-(trifluoromethyl)-4,5-dihydrobenzo[c]oxepin-1(3H)-one

Base Information

• Chemical Name: (R)-3-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-8-fluoro-5,5-dimethyl-3-(trifluoromethyl)-4,5-dihydrobenzo[c]oxepin-1(3H)-one
• CAS No.: 1429053-36-0
• Molecular Formula: C₂₃H₂₂F₄N₂O₄S
• Molecular Weight: 498.498

Synonyms:

Chemical Property of (R)-3-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-8-fluoro-5,5-dimethyl-3-(trifluoromethyl)-4,5-dihydrobenzo[c]oxepin-1(3H)-one

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Technology Process of (R)-3-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-8-fluoro-5,5-dimethyl-3-(trifluoromethyl)-4,5-dihydrobenzo[c]oxepin-1(3H)-one

There total 2 articles about (R)-3-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-8-fluoro-5,5-dimethyl-3-(trifluoromethyl)-4,5-dihydrobenzo[c]oxepin-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-((R)-4-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluoro-N-((S)-1-(4-methoxyphenyl)ethyl)benzamide (1198785-56-6) + methoxybenzene (100-66-3) → 1,1-bis(4-methoxyphenyl)ethane (10543-21-2) + (R)-2-(4-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide anisole solvate (1198785-57-7) + (R)-2-(4-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzoic acid (1429053-35-9) + (R)-3-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-8-fluoro-5,5-dimethyl-3-(trifluoromethyl)-4,5-dihydrobenzo[c]oxepin-1(3H)-one (1429053-36-0) + 2-((4R)-4-((5-(ethylsulfonyl)-3-(1-(4-methoxyphenyl)ethyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide + 1-methoxy-2-(1-(4-methoxyphenyl)ethyl)benzene (28355-22-8)

Guidance literature:

With phosphoric acid; In water; at 100 ℃; for 1.25h; Large scale;

DOI:10.1021/jo400079z

Reference yield: 67.0%

2-((R)-4-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluoro-N-((S)-1-(4-methoxyphenyl)ethyl)benzamide (1198785-56-6) + acetic acid (64-19-7,77671-22-8) → (R)-2-(4-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide acetic acid solvate + (R)-2-(4-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzoic acid (1429053-35-9) + (R)-3-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-8-fluoro-5,5-dimethyl-3-(trifluoromethyl)-4,5-dihydrobenzo[c]oxepin-1(3H)-one (1429053-36-0) + 2-((4R)-4-((5-(ethylsulfonyl)-3-(1-(4-methoxyphenyl)ethyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide

Guidance literature:

With hydrogen bromide; In water; at 80 ℃; for 8h; Large scale;

DOI:10.1021/jo400079z

upstream raw materials:

2-((R)-4-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluoro-N-((S)-1-(4-methoxyphenyl)ethyl)benzamide

acetic acid

methoxybenzene

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