4-(4-(2-aminothiazol-5-yl)-6-((S)-3-methylmorpholino)-1,3,5-triazin-2-yloxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

Base Information

Chemical Name:4-(4-(2-aminothiazol-5-yl)-6-((S)-3-methylmorpholino)-1,3,5-triazin-2-yloxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride
CAS No.:1542268-18-7
Molecular Formula:C₂₀H₂₂FN₇O₃S*ClH
Molecular Weight:495.965
Hs Code.:

Synonyms:

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Chemical Property of 4-(4-(2-aminothiazol-5-yl)-6-((S)-3-methylmorpholino)-1,3,5-triazin-2-yloxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

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Technology Process of 4-(4-(2-aminothiazol-5-yl)-6-((S)-3-methylmorpholino)-1,3,5-triazin-2-yloxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

There total 8 articles about 4-(4-(2-aminothiazol-5-yl)-6-((S)-3-methylmorpholino)-1,3,5-triazin-2-yloxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119844-66-5
(S)-5-methylmorpholin-3-one

: 1542268-18-7
4-(4-(2-aminothiazol-5-yl)-6-((S)-3-methylmorpholino)-1,3,5-triazin-2-yloxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / chloroform / 3 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 90 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; 1,4-dioxane; chloroform; dimethyl sulfoxide;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1542268-18-7
4-(4-(2-aminothiazol-5-yl)-6-((S)-3-methylmorpholino)-1,3,5-triazin-2-yloxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / chloroform / 3 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 90 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; triethylamine; In 1,4-dioxane; chloroform; dimethyl sulfoxide;

Reference yield:

: 94193-79-0
2-chloro-N-((S)-2-hydroxy-1-methylethyl)acetamide

: 1542268-18-7
4-(4-(2-aminothiazol-5-yl)-6-((S)-3-methylmorpholino)-1,3,5-triazin-2-yloxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 0 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: triethylamine / chloroform / 3 h / 0 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 90 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; dimethyl sulfoxide; isopropyl alcohol;