(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone
CAS No.:1616248-98-6
Molecular Formula:C₂₀H₂₄N₂O₂
Molecular Weight:324.423
Hs Code.:

Synonyms:

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Chemical Property of (3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone

Chemical Property:

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Technology Process of (3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone

There total 5 articles about (3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₃ClO₂

: 109-07-9
(RS)-2-methylpiperazine

: 1616248-98-6
(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone

Guidance literature:: With diethylaluminium chloride; In dichloromethane; toluene; at 0 - 20 ℃; for 5h;
DOI:10.1039/c4ob00647j

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 1616248-98-6
(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 18 h / Reflux

2.1: pyridine / dichloromethane / 24 h

3.1: caesium carbonate / tetrahydrofuran

4.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 130 °C / Microwave irradiation

5.1: sodium hydroxide / ethanol / 3 h / Reflux

5.2: pH 4

6.1: thionyl chloride / 1 h / Reflux

7.1: diethylaluminium chloride / dichloromethane; toluene / 5 h / 0 - 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sulfuric acid; diethylaluminium chloride; sodium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; 4.1: |Suzuki Coupling;
DOI:10.1039/c4ob00647j

Reference yield:

: 4143-00-4
ethyl 2,4-dihydroxybenzoate

: 1616248-98-6
(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 24 h

2.1: caesium carbonate / tetrahydrofuran

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 130 °C / Microwave irradiation

4.1: sodium hydroxide / ethanol / 3 h / Reflux

4.2: pH 4

5.1: thionyl chloride / 1 h / Reflux

6.1: diethylaluminium chloride / dichloromethane; toluene / 5 h / 0 - 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; diethylaluminium chloride; sodium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; 3.1: |Suzuki Coupling;
DOI:10.1039/c4ob00647j