Technology Process of 2,2,2-Trifluoro-1,1-diphenyl-ethanesulfonic acid (1S,2R,3R,5S,6S,7R)-6-triisopropylsilanyloxy-4,8-dioxa-tricyclo[5.1.0.03,5]oct-2-yl ester
There total 6 articles about 2,2,2-Trifluoro-1,1-diphenyl-ethanesulfonic acid (1S,2R,3R,5S,6S,7R)-6-triisopropylsilanyloxy-4,8-dioxa-tricyclo[5.1.0.03,5]oct-2-yl ester which
guide to synthetic route it.
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synthetic route:
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![2,2,2-Trifluoro-1,1-diphenyl-ethanesulfonic acid (1S,2R,3R,5S,6S,7R)-6-triisopropylsilanyloxy-4,8-dioxa-tricyclo[5.1.0.0<sup>3,5</sup>]oct-2-yl ester](/Databaselist/images/loading.webp)
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112882-14-1
2,2,2-Trifluoro-1,1-diphenyl-ethanesulfonic acid (1S,2R,3R,5S,6S,7R)-6-triisopropylsilanyloxy-4,8-dioxa-tricyclo[5.1.0.03,5]oct-2-yl ester
- Guidance literature:
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Multi-step reaction with 6 steps
1: 1.) Mg / 1.) ether, 2.) reflux, 1 h
2: 1.) NaH / 1.) ether, room temp., 1 h, 2.) room temp., 70 h
3: 96 percent / H2S, p-TsOH / various solvent(s) / 1 h / 60 °C
4: 96 percent / sulfuryl chloride / diethyl ether / 0.25 h / Ambient temperature
5: 100 percent / CF3CO3H / CH2Cl2 / 0 deg C, 1 h; room temp., 1 h
6: 1.) N-methylimidazole, 2.) CF3CO3H/Na2HPO4 / 1.) CH2Cl2, 0 deg C to room temp., 2.) room temp.
With
1-methyl-1H-imidazole; disodium hydrogenphosphate; sulfuryl dichloride; trifluoroacetyl peroxide; hydrogen sulfide; sodium hydride; toluene-4-sulfonic acid; magnesium;
In
diethyl ether; dichloromethane;
DOI:10.1055/s-1987-28045
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112882-14-1
2,2,2-Trifluoro-1,1-diphenyl-ethanesulfonic acid (1S,2R,3R,5S,6S,7R)-6-triisopropylsilanyloxy-4,8-dioxa-tricyclo[5.1.0.03,5]oct-2-yl ester
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaH / 1.) ether, room temp., 1 h, 2.) room temp., 70 h
2: 96 percent / H2S, p-TsOH / various solvent(s) / 1 h / 60 °C
3: 96 percent / sulfuryl chloride / diethyl ether / 0.25 h / Ambient temperature
4: 100 percent / CF3CO3H / CH2Cl2 / 0 deg C, 1 h; room temp., 1 h
5: 1.) N-methylimidazole, 2.) CF3CO3H/Na2HPO4 / 1.) CH2Cl2, 0 deg C to room temp., 2.) room temp.
With
1-methyl-1H-imidazole; disodium hydrogenphosphate; sulfuryl dichloride; trifluoroacetyl peroxide; hydrogen sulfide; sodium hydride; toluene-4-sulfonic acid;
In
diethyl ether; dichloromethane;
DOI:10.1055/s-1987-28045
-
-
112882-14-1
2,2,2-Trifluoro-1,1-diphenyl-ethanesulfonic acid (1S,2R,3R,5S,6S,7R)-6-triisopropylsilanyloxy-4,8-dioxa-tricyclo[5.1.0.03,5]oct-2-yl ester
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / CF3CO3H / CH2Cl2 / 0 deg C, 1 h; room temp., 1 h
2: 1.) N-methylimidazole, 2.) CF3CO3H/Na2HPO4 / 1.) CH2Cl2, 0 deg C to room temp., 2.) room temp.
With
1-methyl-1H-imidazole; disodium hydrogenphosphate; trifluoroacetyl peroxide;
In
dichloromethane;
DOI:10.1055/s-1987-28045
