C₂₁H₂₀FNO₆

Base Information

• Chemical Name: C₂₁H₂₀FNO₆
• CAS No.: 92514-00-6
• Molecular Formula: C₂₁H₂₀FNO₆
• Molecular Weight: 401.391
• Mol file: 92514-00-6.mol

Synonyms:

Chemical Property of C₂₁H₂₀FNO₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₀FNO₆

There total 10 articles about C₂₁H₂₀FNO₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-7-methylbenzofuran-2-carboxylic acid (55364-64-2) → C21H20FNO6 (92514-00-6)

Guidance literature:

Multi-step reaction with 6 steps

1: aq. NaOH, 5percent sodium amalgam / 5 h

2: 50 percent / H₂SO₄ / Ambient temperature

3: 68 percent / AlCl₃ / 1,2-dichloro-ethane / 0.17 h / 0 - 5 °C

4: 93 percent / BBr₃ / CH₂Cl₂ / 0.25 h

5: 21 percent / NH₂OH*HCl, pyridine / 4 h / Heating

6: 1 h / 90 °C

With pyridine; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; boron tribromide; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00374a014

Reference yield:

2,4-dimethoxy-3-methylbenzaldehyde (7149-92-0) → C21H20FNO6 (92514-00-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 75 percent / BBr₃ / CH₂Cl₂ / 1 h / 0 °C

2: K₂CO₃ / butan-2-one / 4 h / Heating

3: ethanolic KOH

4: aq. NaOH, 5percent sodium amalgam / 5 h

5: 50 percent / H₂SO₄ / Ambient temperature

6: 68 percent / AlCl₃ / 1,2-dichloro-ethane / 0.17 h / 0 - 5 °C

7: 93 percent / BBr₃ / CH₂Cl₂ / 0.25 h

8: 21 percent / NH₂OH*HCl, pyridine / 4 h / Heating

9: 1 h / 90 °C

With pyridine; potassium hydroxide; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; boron tribromide; potassium carbonate; In dichloromethane; 1,2-dichloro-ethane; butanone;

DOI:10.1021/jm00374a014

Reference yield:

2-hydroxy-4-methoxy-3-methylbenzaldehyde (54700-36-6) → C21H20FNO6 (92514-00-6)

Guidance literature:

Multi-step reaction with 8 steps

1: K₂CO₃ / butan-2-one / 4 h / Heating

2: ethanolic KOH

3: aq. NaOH, 5percent sodium amalgam / 5 h

4: 50 percent / H₂SO₄ / Ambient temperature

5: 68 percent / AlCl₃ / 1,2-dichloro-ethane / 0.17 h / 0 - 5 °C

6: 93 percent / BBr₃ / CH₂Cl₂ / 0.25 h

7: 21 percent / NH₂OH*HCl, pyridine / 4 h / Heating

8: 1 h / 90 °C

With pyridine; potassium hydroxide; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; boron tribromide; potassium carbonate; In dichloromethane; 1,2-dichloro-ethane; butanone;

DOI:10.1021/jm00374a014

upstream raw materials:

acetic anhydride

ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methylbenzofuran-2-carboxylate oxime

6-methoxy-7-methylbenzofuran-2-carboxylic acid

2-hydroxy-4-methoxy-3-methylbenzaldehyde

Downstream raw materials:

3-(o-fluorophenyl)-5,6-dihydro-8-methylfuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acid

ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methylfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate