Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate

Base Information Edit

Chemical Name:Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate
CAS No.:2053424-88-5
Molecular Formula:C₂₁H₂₉N₆O₅P
Molecular Weight:476.472
Hs Code.:
UNII:K9U5THV8UZ
Mol file:2053424-88-5.mol

Synonyms:K9U5THV8UZ;UNII-K9U5THV8UZ;2053424-88-5;Tenofovir alafenamide rrr diastereomer;Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate;D-Alanine, N-((R)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester;F19341

Suppliers and Price of Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
D-AlanineN-[(R)-[[(1R)-2-(6-Amino-9Hpurin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-1-methylethylEster
10mg
$ 700.00

Total 8 raw suppliers

Chemical Property of Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate Edit

Chemical Property:

Melting Point:134 - 138°C
Boiling Point:640.4±65.0 °C(Predicted)
PKA:4.21±0.10(Predicted)
Density:1.39±0.1 g/cm3(Predicted)
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly, Sonicated)
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:12
Exact Mass:476.19370504
Heavy Atom Count:33
Complexity:680

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-AlanineN-[(R)-[[(1R)-2-(6-Amino-9Hpurin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-1-methylethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3
Isomeric SMILES:C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@](=O)(N[C@H](C)C(=O)OC(C)C)OC3=CC=CC=C3
Uses (R)-isopropyl 2-(((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate is an impurity of Tenofovir (T018500) which is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.

Technology Process of Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate

There total 98 articles about Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 39825-33-7
isopropyl L-alanine

: (((R)-1-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphonyl chloride

: 379270-37-8,2053424-88-5,379270-36-7
(S)-isopropyl-2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: (((R)-1-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphonyl chloride; In Isopropyl acetate; at -20 ℃; for 1h;

isopropyl L-alanine; In Isopropyl acetate; at -20 - 20 ℃; for 2h;