5-(2'-methoxy-4'-methylphenyl)hexanoic acid

Base Information

• Chemical Name: 5-(2'-methoxy-4'-methylphenyl)hexanoic acid
• CAS No.: 122427-55-8
• Molecular Formula: C₁₄H₂₀O₃
• Molecular Weight: 236.311
• Mol file: 122427-55-8.mol

Synonyms:

Chemical Property of 5-(2'-methoxy-4'-methylphenyl)hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2'-methoxy-4'-methylphenyl)hexanoic acid

There total 18 articles about 5-(2'-methoxy-4'-methylphenyl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(2'-methoxy-4'-methylphenyl)-5-hydroxy-(2E)-pentanoate (164921-74-8) → 5-(2'-methoxy-4'-methylphenyl)hexanoic acid (122427-55-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / H₂, 20percent Pd(OH)2/C / ethyl acetate / 760 Torr / Ambient temperature

2: pyridine / Ambient temperature

3: 63 percent / NaBH₄ / dimethylsulfoxide / 3 h / 80 °C

4: 89 percent / triphenylphosphine, imidazole, iodine / acetonitrile; diethyl ether / 0.5 h / 0 °C

5: 98 percent / dimethylformamide / Ambient temperature

6: 2N NaOH / ethanol / 12 h / Heating

With 1H-imidazole; palladium dihydroxide; sodium hydroxide; sodium tetrahydroborate; hydrogen; iodine; triphenylphosphine; In pyridine; diethyl ether; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1248/cpb.43.553

Reference yield:

5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester (170235-79-7) → 5-(2'-methoxy-4'-methylphenyl)hexanoic acid (122427-55-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / Ambient temperature

2: 63 percent / NaBH₄ / dimethylsulfoxide / 3 h / 80 °C

3: 89 percent / triphenylphosphine, imidazole, iodine / acetonitrile; diethyl ether / 0.5 h / 0 °C

4: 98 percent / dimethylformamide / Ambient temperature

5: 2N NaOH / ethanol / 12 h / Heating

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; iodine; triphenylphosphine; In pyridine; diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1248/cpb.43.553

Reference yield:

methyl 4-(2'-methoxy-4'-methylphenyl)-5-tosyloxypentanoate (170235-80-0) → 5-(2'-methoxy-4'-methylphenyl)hexanoic acid (122427-55-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / NaBH₄ / dimethylsulfoxide / 3 h / 80 °C

2: 89 percent / triphenylphosphine, imidazole, iodine / acetonitrile; diethyl ether / 0.5 h / 0 °C

3: 98 percent / dimethylformamide / Ambient temperature

4: 2N NaOH / ethanol / 12 h / Heating

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; iodine; triphenylphosphine; In diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1248/cpb.43.553

upstream raw materials:

5-(2'-methoxy-4'-methylphenyl)hex-2-enoic acid

5-(2-Methoxy-4-methyl-phenyl)-hex-5-enoic acid

4-(2'-methoxy-4'-methylphenyl)hexanenitrile

4-(2'-methoxy-4'-methylphenyl)pentanol

Downstream raw materials:

methyl 5-(2'-methoxy-4'-methylphenyl)hexanoate

5-(2-Hydroxy-4-methyl-phenyl)-hexanoic acid

methyl-5-(2'-hydroxy-4'-methylphenyl)hexanoate

8-Methoxycalamenene