C₃₂H₃₅IN₂O₇S

Base Information

• Chemical Name: C₃₂H₃₅IN₂O₇S
• CAS No.: 154377-83-0
• Molecular Formula: C₃₂H₃₅IN₂O₇S
• Molecular Weight: 718.61
• Mol file: 154377-83-0.mol

Synonyms:

Chemical Property of C₃₂H₃₅IN₂O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₅IN₂O₇S

There total 8 articles about C₃₂H₃₅IN₂O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

N-(tert-butyloxycarbonyl)-4-iodobenzenesulfonamide (154377-75-0) + 5-[7-(2-Hydroxy-ethyl)-11H-10-oxa-3-aza-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-pentanoic acid methyl ester (154377-81-8) → C32H35IN2O7S (154377-83-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)61429-6

Reference yield:

methyl hex-5-ynoate (77758-51-1) → C32H35IN2O7S (154377-83-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 31 percent / (Ph₃P)4Pd, CuI, dicyclohexylamine / acetonitrile

2: 95 percent / Bu₄NF / tetrahydrofuran

3: 99 percent / imidazole / dimethylformamide

4: 55 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

5: 94 percent / Bu₄NF / tetrahydrofuran

6: 60 percent / Pd(OAc)2, tri-o-tolylphosphine, HCO₂H, piperidine / acetonitrile

7: 23 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

With piperidine; 1H-imidazole; palladium diacetate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; tetrabutyl ammonium fluoride; N-cyclohexyl-cyclohexanamine; triphenylphosphine; tris-(o-tolyl)phosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(00)61429-6

Reference yield:

6-[2-Hydroxy-5-(2-hydroxy-ethyl)-phenyl]-hex-5-ynoic acid methyl ester → C32H35IN2O7S (154377-83-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / imidazole / dimethylformamide

2: 55 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

3: 94 percent / Bu₄NF / tetrahydrofuran

4: 60 percent / Pd(OAc)2, tri-o-tolylphosphine, HCO₂H, piperidine / acetonitrile

5: 23 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

With piperidine; 1H-imidazole; palladium diacetate; formic acid; tetrabutyl ammonium fluoride; triphenylphosphine; tris-(o-tolyl)phosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(00)61429-6

upstream raw materials:

N-(tert-butyloxycarbonyl)-4-iodobenzenesulfonamide

5-[7-(2-Hydroxy-ethyl)-11H-10-oxa-3-aza-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-pentanoic acid methyl ester

methyl hex-5-ynoate

6-{5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-hydroxy-phenyl}-hex-5-ynoic acid methyl ester