N-[3-(2-acetamidothiazol-4-yl)phenyl]-5-bromopentanamide

Base Information

Chemical Name:N-[3-(2-acetamidothiazol-4-yl)phenyl]-5-bromopentanamide
CAS No.:1353640-97-7
Molecular Formula:C₁₆H₁₈BrN₃O₂S
Molecular Weight:396.308
Hs Code.:

Synonyms:

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Chemical Property of N-[3-(2-acetamidothiazol-4-yl)phenyl]-5-bromopentanamide

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Technology Process of N-[3-(2-acetamidothiazol-4-yl)phenyl]-5-bromopentanamide

There total 2 articles about N-[3-(2-acetamidothiazol-4-yl)phenyl]-5-bromopentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2067-33-6
5-bromopentanoic acid

: 134812-30-9
N-(4-(3'-aminophenyl)thiazol-2-yl)acetamide

: 1353640-97-7
N-[3-(2-acetamidothiazol-4-yl)phenyl]-5-bromopentanamide

Guidance literature:: 5-bromopentanoic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 0.333333h; Inert atmosphere;

N-(4-(3'-aminophenyl)thiazol-2-yl)acetamide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/bi2012959

Reference yield:

: 14660-52-7
ethyl 5-bromovalerate

: 1353640-97-7
N-[3-(2-acetamidothiazol-4-yl)phenyl]-5-bromopentanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / methanol / 0.5 h / 20 °C

2.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1021/bi2012959