2-methyl-N-(pyridin-2-ylmethyl)propan-2-amine

Base Information

• Chemical Name: 2-methyl-N-(pyridin-2-ylmethyl)propan-2-amine
• CAS No.: 58669-32-2
• Molecular Formula: C₁₀H₁₆N₂
• Molecular Weight: 164.25
• DSSTox Substance ID: DTXSID80406026
• Nikkaji Number: J2.181.267F
• Wikidata: Q82210864
• Mol file: 58669-32-2.mol

Synonyms:58669-32-2;2-methyl-N-(pyridin-2-ylmethyl)propan-2-amine;2-METHYL-N-(2-PYRIDINYLMETHYL)-2-PROPANAMINE;N-tert-Butyl-N-(pyridin-2-ylmethyl)amine;N-t-butyl-2-picolinamine;SCHEMBL7749926;DTXSID80406026;2-(tert-Butylaminomethyl)pyridine;STK511424;AKOS000152876;tert-butyl[(pyridin-2-yl)methyl]amine;BB 0218998;EN300-51554;2-Methyl-N-[(pyridin-2-yl)methyl]propan-2-amine;2-Methyl-N-(2-pyridinylmethyl)-2-propanamine x1hcl;N-(TERT-BUTYL)-N-(PYRIDIN-2-YLMETHYL)AMINE;Z111725492

Chemical Property of 2-methyl-N-(pyridin-2-ylmethyl)propan-2-amine

Chemical Property:

• Vapor Pressure: 0.0789mmHg at 25°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 164.131348519
• Heavy Atom Count: 12
• Complexity: 126

Purity/Quality:

97% ^*data from raw suppliers

2-methyl-N-(pyridin-2-ylmethyl)propan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)NCC1=CC=CC=N1

Technology Process of 2-methyl-N-(pyridin-2-ylmethyl)propan-2-amine

There total 5 articles about 2-methyl-N-(pyridin-2-ylmethyl)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-methyl-N-(pyridin-2-ylmethylene)propan-2-amine (21478-42-2) → 2-(tert-Butyl)-aminomethyl-pyridin (58669-32-2)

Guidance literature:

2-methyl-N-(pyridin-2-ylmethylene)propan-2-amine; With sodium tetrahydroborate; In methanol; at 25 ℃;

With water; In methanol;

DOI:10.1039/b912068h

Reference yield: 66.0%

pyridine-2-carbaldehyde (1121-60-4) + tert-butylamine (75-64-9) → 2-(tert-Butyl)-aminomethyl-pyridin (58669-32-2)

Guidance literature:

With carbon monoxide; 5% rhodium-on-charcoal; In tetrahydrofuran; at 160 ℃; for 20h; under 38002.6 Torr; Autoclave;

DOI:10.1002/cctc.201500493

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → 2-(tert-Butyl)-aminomethyl-pyridin (58669-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: sodium borohydride / methanol / 3 h

With sodium tetrahydroborate; In methanol; benzene;

DOI:10.1002/mrc.1260250808

upstream raw materials:

(E)-N-(pyridin-2-ylmethylene)tert-butylamine

pyridine-2-carbaldehyde

2-methyl-N-(pyridin-2-ylmethylene)propan-2-amine

tert-butylamine