Benzene, 1-bromo-2-(diethoxymethyl)-4-methoxy-

Base Information

• Chemical Name: Benzene, 1-bromo-2-(diethoxymethyl)-4-methoxy-
• CAS No.: 139962-94-0
• Molecular Formula: C12H17BrO3
• Molecular Weight: 289.16600
• Mol file: 139962-94-0.mol

Synonyms:1-bromo-4-methoxy-2-(diethoxymethyl)benzene;1-Bromo-2-diethoxymethyl-4-methoxy-benzene;

Chemical Property of Benzene, 1-bromo-2-(diethoxymethyl)-4-methoxy-

Chemical Property:

• PSA: 27.69000
• LogP: 3.52930

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-bromo-2-(diethoxymethyl)-4-methoxy-

There total 1 articles about Benzene, 1-bromo-2-(diethoxymethyl)-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-5-methoxy-benzaldehyde (7507-86-0) + orthoformic acid triethyl ester (122-51-0) → 2-Bromo-5-methoxybenzaldehyde diethyl acetal (139962-94-0)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 6h; Reflux;

DOI:10.1021/acs.joc.9b01677

Reference yield: 88.0%

2-Bromo-5-methoxybenzaldehyde diethyl acetal (139962-94-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → C13H18O4

Guidance literature:

2-Bromo-5-methoxybenzaldehyde diethyl acetal; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/acs.joc.9b01677

Reference yield: 73.0%

4-chlorobenzaldehyde (104-88-1) + 2-Bromo-5-methoxybenzaldehyde diethyl acetal (139962-94-0) → (4-chlorophenyl)(2-(diethoxymethyl)-4-methoxyphenyl)methanol (1609471-95-5)

Guidance literature:

2-Bromo-5-methoxybenzaldehyde diethyl acetal; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h; Inert atmosphere;

4-chlorobenzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201300868

upstream raw materials:

2-bromo-5-methoxy-benzaldehyde

orthoformic acid triethyl ester

Downstream raw materials:

C₁₄H₁₉NO₂

C₂₀H₃₂N₂O

C₂₁H₃₁N₂O⁽¹⁺⁾*Cl^(1-)

(2-(diethoxymethyl)-4-methoxyphenyl)(phenyl)methanol