Technology Process of 2-(Dibenzo[b,e]borinin-5(10h)-yloxy)ethanamine
There total 7 articles about 2-(Dibenzo[b,e]borinin-5(10h)-yloxy)ethanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
boric acid tributyl ester; 2-bromo-1-(2-bromobenzyl)-4-methylbenzene;
With
iodine; magnesium;
In
tetrahydrofuran;
at 20 ℃;
for 73h;
Inert atmosphere;
ethanolamine;
In
ethyl acetate;
at 20 ℃;
Inert atmosphere;
DOI:10.1002/chem.202003319
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran; benzene;
(Ar); to THF soln. of Grignard reagent was added boron compd. in benzene and react. quenched after 15 min with aq. HCl, soln. was extd. with ether, dried (Na2SO4) exts. evapd. in vac. and residual oil treated with ethanolamine; after 5 min mixt. was poured into ether/water (1:1), pptd. product was filtered off and recrystd. from EtOH;
DOI:10.1021/ja00319a032
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / -20 °C / Inert atmosphere
1.2: 0.75 h / -20 - -15 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C
2.2: 16 h / 0 - 20 °C
3.1: iodine; magnesium / tetrahydrofuran / 73 h / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
iodine; isopropylmagnesium chloride; magnesium; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.202003319
