3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine

Base Information

• Chemical Name: 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine
• CAS No.: 641571-16-6
• Molecular Formula: C₁₁H₁₀F₃N₃
• Molecular Weight: 241.216
• Mol file: 641571-16-6.mol

Synonyms:

Chemical Property of 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine

Chemical Property:

• Melting Point: 131-133oC
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine is used in the preparation of c-Src and Abl inhibitors based on the scaffold present in Imatinib (G407000), used in the treatment of myelogenic leukemia. 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine is used in the preparation of c-Src and Abl inhibitors based on the scaffold present in Imatinib (G407000), used in the treatment of myelogenic leukemia. It is a COVID19-related research product.

Technology Process of 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine

There total 3 articles about 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.2%

4-methyl-1H-imidazole (822-36-6) + 3-iodo-5-trifluoromethylaniline (389571-69-1) → 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-11-1) + 3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-16-6)

Guidance literature:

With potassium phosphate; at 110 ℃; for 30h; Reagent/catalyst;

Reference yield: 64.9%

4-methyl-1H-imidazole (822-36-6) + [3-bromo-5-(trifluoromethyl)phenyl]amine (54962-75-3) → 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-11-1) + 3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-16-6)

Guidance literature:

With copper(l) iodide; caesium carbonate; rac-diaminocyclohexane; In diethylene glycol dimethyl ether; at 24 ℃; for 24h; Reagent/catalyst; Inert atmosphere;

Reference yield:

→ 3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-16-6)

Guidance literature:

upstream raw materials:

4-methyl-1H-imidazole

[3-bromo-5-(trifluoromethyl)phenyl]amine

3-iodo-5-trifluoromethylaniline