1-(2-Chloro-acetyl)-piperidin-4-one

Base Information

Chemical Name:1-(2-Chloro-acetyl)-piperidin-4-one
CAS No.:71072-30-5
Molecular Formula:C₇H₁₀ClNO₂
Molecular Weight:175.615
Hs Code.:
DSSTox Substance ID:DTXSID50593391
Wikidata:Q82487876
Mol file:71072-30-5.mol

Synonyms:1-(2-Chloro-acetyl)-piperidin-4-one;71072-30-5;1-(2-Chloroacetyl)piperidin-4-one;SCHEMBL5544595;1-(Chloroacetyl)piperidin-4-one;DTXSID50593391;SUMDXWHOKYLFHF-UHFFFAOYSA-N;AM101177;DB-300413;EN300-22593

Suppliers and Price of 1-(2-Chloro-acetyl)-piperidin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
1-(2-chloroacetyl)-4-Piperidinone 97.00%
25G
$ 4010.00

AccelPharmtech
1-(2-chloroacetyl)-4-Piperidinone 97.00%
5G
$ 2180.00

AccelPharmtech
1-(2-chloroacetyl)-4-Piperidinone 97.00%
1G
$ 1940.00

Total 6 raw suppliers

Chemical Property of 1-(2-Chloro-acetyl)-piperidin-4-one

Chemical Property:

XLogP3:-0.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:175.0400063
Heavy Atom Count:11
Complexity:171

Purity/Quality:

99% ^*data from raw suppliers

1-(2-chloroacetyl)-4-Piperidinone 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1=O)C(=O)CCl

Technology Process of 1-(2-Chloro-acetyl)-piperidin-4-one

There total 2 articles about 1-(2-Chloro-acetyl)-piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 848438-60-8
N-chloroacetyl-4-hydroxypiperidine

: 71072-30-5
1-(2-chloroacetyl)piperidin-4-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;
DOI:10.1021/jo800341k

Reference yield:

: 41661-47-6
piperidin-4-one

: 79-04-9
chloroacetyl chloride

: 71072-30-5
1-(2-chloroacetyl)piperidin-4-one

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1111/cbdd.13790

Reference yield:

: 71072-30-5
1-(2-chloroacetyl)piperidin-4-one

: (2E)-1-[15-(azidoacetyl)-7,11,18,21-tetraoxa-3,15-diazatrispiro[5.2.2.5¹².2⁹.2⁶]heneicos-3-yl]-3-phenylprop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; benzene / 140 °C / Dean-Stark

2: sodium azide / N,N-dimethyl-formamide / 2 h / 20 °C

3: sodium hydride; chloro-trimethyl-silane / diethyl ether; mineral oil / 1 h / 0 °C

With chloro-trimethyl-silane; sodium azide; sodium hydride; toluene-4-sulfonic acid; In diethyl ether; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.3762/bjoc.11.11