((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-3,4-dihydro-7H-imidazo[4,5-d][1,2,3]triazin-7-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate

Base Information

Chemical Name:((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-3,4-dihydro-7H-imidazo[4,5-d][1,2,3]triazin-7-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate
CAS No.:36519-18-3
Molecular Formula:C₉H₁₂N₅O₈P
Molecular Weight:349.197
Hs Code.:

Synonyms:

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Chemical Property of ((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-3,4-dihydro-7H-imidazo[4,5-d][1,2,3]triazin-7-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate

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Technology Process of ((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-3,4-dihydro-7H-imidazo[4,5-d][1,2,3]triazin-7-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate

There total 10 articles about ((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-3,4-dihydro-7H-imidazo[4,5-d][1,2,3]triazin-7-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1643356-30-2
C₂₃H₂₄N₅O₈P

: 36519-18-3
((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-3,4-dihydro-7H-imidazo[4,5-d][1,2,3]triazin-7-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 0.5h;
DOI:10.1039/c4ob00705k

Reference yield:

: 58-63-9
inosine

: 36519-18-3
((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-3,4-dihydro-7H-imidazo[4,5-d][1,2,3]triazin-7-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1H-imidazole; tert-butyldimethylsilyl chloride / N,N-dimethyl-formamide / 48 h / 20 - 60 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 - 60 °C / Inert atmosphere

3.1: ethylenediamine / tetrahydrofuran / 3 h / 20 - 50 °C / Inert atmosphere

4.1: ammonium fluoride / water; N,N-dimethyl-formamide / 24 h / 20 °C

5.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 1 h / 0 °C

6.1: ethylenediamine / N,N-dimethyl-formamide / 2 h / 20 - 60 °C

7.1: 1H-tetrazole / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

7.2: 1 h / -78 - 0 °C / Inert atmosphere

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

9.1: 5%-palladium/activated carbon; hydrogen / methanol / 0.5 h / 20 °C

With 1H-imidazole; 1H-tetrazole; hydrogenchloride; ammonium fluoride; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; tert-butyldimethylsilyl chloride; ethylenediamine; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c4ob00705k

Reference yield:

: 1643356-25-5
5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

: 36519-18-3
((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-3,4-dihydro-7H-imidazo[4,5-d][1,2,3]triazin-7-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium fluoride / water; N,N-dimethyl-formamide / 24 h / 20 °C

2.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 1 h / 0 °C

3.1: ethylenediamine / N,N-dimethyl-formamide / 2 h / 20 - 60 °C

4.1: 1H-tetrazole / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

4.2: 1 h / -78 - 0 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

6.1: 5%-palladium/activated carbon; hydrogen / methanol / 0.5 h / 20 °C

With 1H-tetrazole; hydrogenchloride; ammonium fluoride; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; ethylenediamine; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c4ob00705k