4-bromo-2,3-dihydro-1H-inden-5-amine

Base Information

• Chemical Name: 4-bromo-2,3-dihydro-1H-inden-5-amine
• CAS No.: 676265-54-6
• Molecular Formula: C₉H₁₀BrN
• Molecular Weight: 212.089
• Mol file: 676265-54-6.mol

Synonyms:

Chemical Property of 4-bromo-2,3-dihydro-1H-inden-5-amine

Chemical Property:

• Melting Point: 50-51 °C
• Boiling Point: 310.3±42.0 °C(Predicted)
• PKA: 3.11±0.20(Predicted)
• Density: 1.548±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-bromo-2,3-dihydro-1H-inden-5-amine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2,3-dihydro-1H-inden-5-amine

There total 6 articles about 4-bromo-2,3-dihydro-1H-inden-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4,6-dibromo-2,3-dihydro-1H-inden-5-amine (214697-92-4) → 4-bromo-2,3-dihydro-1H-inden-5-amine (676265-54-6)

Guidance literature:

With hydrogenchloride; acetic acid; tin(ll) chloride; In water; at 120 ℃; for 0.5h;

Reference yield:

indan-5-amine (24425-40-9) → 4-bromo-2,3-dihydro-1H-inden-5-amine (676265-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid / 20 °C

2: hydrogenchloride; acetic acid; tin(ll) chloride / water / 1.5 h / 95 °C

With hydrogenchloride; bromine; acetic acid; tin(ll) chloride; In water;

Reference yield:

6-bromo-2,3-dihydro-1H-inden-5-amine (53474-09-2) → 4-bromo-2,3-dihydro-1H-inden-5-amine (676265-54-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / Behandeln des Reaktionsgemisches mit Brom

2: sulfuric acid / Eintragen der Reaktionsloesung in Wasser

3: ethanol; tin; aqueous hydrochloric acid

With pyridine; hydrogenchloride; tin; ethanol; sulfuric acid;

DOI:10.1039/jr9370001103

upstream raw materials:

4,6-dibromo-2,3-dihydro-1H-inden-5-amine

hydrogenchloride

ethanol

6-bromo-2,3-dihydro-1H-inden-5-amine

Downstream raw materials:

C₂₅H₂₁F₂N₃O₄S

C₂₆H₂₃F₂N₃O₄S

C₂₇H₂₄F₂N₂O₃

C₂₅H₂₀F₂N₂O₃

Refernces

• 1、 -. "3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF". Paragraph 00247. . Retrieved 2017/10/06.
• 2、 -. "4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS". Page/Page column 122-123. . Retrieved 2008/12/07.