4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile

Base Information

Chemical Name:4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile
CAS No.:622369-26-0
Molecular Formula:C₂₅H₂₆Cl₂N₄O₃
Molecular Weight:501.412
Hs Code.:
DSSTox Substance ID:DTXSID40416202
ChEMBL ID:CHEMBL296844

Synonyms:4-phenylamino-3-quinolinecarbonitrile 9;BDBM6098;CHEMBL296844;SCHEMBL6183286;DTXSID40416202;4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile;4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methyl-2-piperidinyl)methoxy]-3-quinolinecarbonitrile;4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile;622369-26-0

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Chemical Property of 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile

Chemical Property:

Vapor Pressure:1.6E-14mmHg at 25°C
XLogP3:6.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:500.1381961
Heavy Atom Count:34
Complexity:709

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCCCC1COC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC

Technology Process of 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile

There total 6 articles about 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 20845-34-5
(1-methyl-piperidin-2-yl)-methanol

: 622369-46-4
4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile

: 622369-26-0
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidine-2-yl)methoxy]quinoline-3-carbonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 125 ℃; for 3h;
DOI:10.1021/jm0499458

Reference yield:

: 366-99-4
3-fluoro-4-methoxyaniline

: 622369-26-0
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidine-2-yl)methoxy]quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 42 percent / toluene / 4.5 h / 100 - 110 °C

2: 77 percent / POCl₃ / 0.5 h / Heating

3: 69 percent / pyridine hydrochloride / 2-ethoxy-ethanol / 3 h / 120 °C

4: 59 percent / NaH / dimethylformamide / 3 h / 125 °C

With pyridine hydrochloride; sodium hydride; trichlorophosphate; In 2-ethoxy-ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0499458

Reference yield:

: 98446-49-2
2,4-dichloro-5-methoxyaniline

: 622369-26-0
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidine-2-yl)methoxy]quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / pyridine hydrochloride / 2-ethoxy-ethanol / 3 h / 120 °C

2: 59 percent / NaH / dimethylformamide / 3 h / 125 °C

With pyridine hydrochloride; sodium hydride; In 2-ethoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0499458