5-bromo-1-methyl-1H-indole-2,3-dione 3-oxime

Base Information

• Chemical Name: 5-bromo-1-methyl-1H-indole-2,3-dione 3-oxime
• CAS No.: 69736-60-3
• Molecular Formula: C₉H₇BrN₂O₂
• Molecular Weight: 255.071
• Mol file: 69736-60-3.mol

Synonyms:

Chemical Property of 5-bromo-1-methyl-1H-indole-2,3-dione 3-oxime

Chemical Property:

Purity/Quality:

5-BROMO-1-METHYL-1H-INDOLE-2,3-DIONE 3-OXIME 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-1-methyl-1H-indole-2,3-dione 3-oxime

There total 5 articles about 5-bromo-1-methyl-1H-indole-2,3-dione 3-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-bromo-1-methyl-1H-indole-2,3-dione (2058-72-2) → 5-bromo-1-methyl-indoline-2,3-dione-3-oxime (69736-60-3)

Guidance literature:

With hydrogenchloride; hydroxylamine hydrochloride; In ethanol; water; for 1h; Heating;

DOI:10.1007/BF00761998

Reference yield: 67.0%

5-bromo-1-methyl-1,3-dihydro-indol-2-one (20870-90-0) → 5-bromo-3-(hydroxyimino)-1-methylindolin-2-one (69736-60-3)

Guidance literature:

With tert.-butylnitrite; In water; at 20 ℃; for 18h; Schlenk technique; Green chemistry;

DOI:10.1039/c7ob01235g

Reference yield:

5-Bromo-1H-indole-2,3-dione (87-48-9) → 5-bromo-1-methyl-indoline-2,3-dione-3-oxime (69736-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaOCH₃ / 1.) methanol; 2.) reflux

2: 84 percent / NH₃OH*HCl, conc.HCl / H₂O; ethanol / 1 h / Heating

With hydrogenchloride; hydroxylamine hydrochloride; sodium methylate; In ethanol; water;

DOI:10.1007/BF00761998

upstream raw materials:

5-bromo-1-methyl-1,3-dihydro-indol-2-one

isopentyl nitrite

5-bromo-1-methyl-1H-indole-2,3-dione

5-Bromo-1H-indole-2,3-dione

Refernces

• 1、 Pinkin, L. D.,Dzyubenko, V. G.,Abramenko, P. I.,Shpileva, I. P.. "SYNTHESIS OF SUBSTITUTED THIENOTHIAZOLES AND INDOLOTHIAZOLES". . p. 345 - 352. Retrieved 2007/10/02.