8-Methoxy-1,3-dimethylpyrimido[4,5-b]quinoline-2,4-dione

Base Information

Chemical Name:8-Methoxy-1,3-dimethylpyrimido[4,5-b]quinoline-2,4-dione
CAS No.:73029-29-5
Molecular Formula:C₁₄H₁₃N₃O₃
Molecular Weight:271.276
Hs Code.:
DSSTox Substance ID:DTXSID30382987
Wikidata:Q82174508

Synonyms:8-methoxy-1,3-dimethylpyrimido[4,5-b]quinoline-2,4-dione;73029-29-5;ZINC00088274;Oprea1_303663;DTXSID30382987

Suppliers and Price of 8-Methoxy-1,3-dimethylpyrimido[4,5-b]quinoline-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Methoxy-1,3-dimethylpyrimido[4,5-b]quinoline-2,4-dione

Chemical Property:

Vapor Pressure:8.62E-09mmHg at 25°C
XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:271.09569129
Heavy Atom Count:20
Complexity:428

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C2=C(C=C3C=CC(=CC3=N2)OC)C(=O)N(C1=O)C

Technology Process of 8-Methoxy-1,3-dimethylpyrimido[4,5-b]quinoline-2,4-dione

There total 5 articles about 8-Methoxy-1,3-dimethylpyrimido[4,5-b]quinoline-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 43192-31-0
2-bromo-4-methoxybenzaldehyde

: 73029-29-5
1,3-Dimethyl-8-methoxy-2,4(1H,3H)-pyrimido<4,5-b>chinolindion

Guidance literature:: 6-Amino-1,3-dimethylbarbituric acid; 2-bromo-4-methoxybenzaldehyde; With potassium carbonate; In N,N-dimethyl-d₆-formamide; at 20 ℃;

With copper dichloride; In N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/acs.joc.7b03272

Reference yield: 70.0%

: 77603-09-9
1,3-dimethyl-8-methoxy-5-methylthiopyrimido<4,5-b>quinoline-2,4(1H,3H)-dione

: 73029-29-5
1,3-Dimethyl-8-methoxy-2,4(1H,3H)-pyrimido<4,5-b>chinolindion

Guidance literature:: With nickel;

Reference yield:

: 26668-99-5
6-(3-methoxy-anilino)-1,3-dimethyl-1H-pyrimidine-2,4-dione

: 73029-29-5
1,3-Dimethyl-8-methoxy-2,4(1H,3H)-pyrimido<4,5-b>chinolindion

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOH / 1.) DMSO

2: 70 percent / Raney-Ni

With sodium hydroxide; nickel;