2-Bromo-4-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Bromo-4-methoxybenzaldehyde
• CAS No.: 43192-31-0
• Molecular Formula: C8H7BrO2
• Molecular Weight: 215.046
• Hs Code.: 2913000090
• European Community (EC) Number: 803-852-9
• DSSTox Substance ID: DTXSID00456205
• Nikkaji Number: J464.511A
• Wikidata: Q72446049
• Mol file: 43192-31-0.mol

Synonyms:2-Bromo-4-methoxybenzaldehyde;43192-31-0;Benzaldehyde, 2-bromo-4-methoxy-;MFCD09788636;2-bromo-4-methoxy-benzaldehyde;SCHEMBL437463;DTXSID00456205;ODISAUHBLBVQKC-UHFFFAOYSA-N;CL8977;AKOS013400295;AM61533;CS-W007358;GS-4438;AC-28560;SY026349;2-Bromo-4-methoxybenzaldehyde, AldrichCPR;FT-0648237;EN300-189698;A826211;Z1190318854

Chemical Property of 2-Bromo-4-methoxybenzaldehyde

Chemical Property:

• Melting Point: 68-69℃
• Boiling Point: 283.927 °C at 760 mmHg
• Flash Point: 125.515 °C
• PSA: 26.30000
• Density: 1.522 g/cm³
• LogP: 2.27020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 213.96294
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C=O)Br

Technology Process of 2-Bromo-4-methoxybenzaldehyde

There total 11 articles about 2-Bromo-4-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-methoxyphenyl bromide (2398-37-0) + acetyl chloride (75-36-5) → 2-bromo-4-methoxybenzaldehyde (43192-31-0)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.tet.2010.05.057

Reference yield: 67.0%

4-methoxy-benzaldehyde (123-11-5) → 2-bromo-4-methoxybenzaldehyde (43192-31-0)

Guidance literature:

4-methoxy-benzaldehyde; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Inert atmosphere;

With carbon tetrabromide; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.087

Reference yield: 49.8%

p-Anisaldehyde dimethyl acetal (2186-92-7) → 2-bromo-4-methoxybenzaldehyde (43192-31-0)

Guidance literature:

With carbon tetrabromide; Inert atmosphere;

DOI:10.1016/j.bmc.2012.11.011

upstream raw materials:

3-bromo-4-methylanisole

p-Anisaldehyde dimethyl acetal

4-methoxy-benzaldehyde

3-methoxyphenyl bromide

Downstream raw materials:

2-bromo-4-methoxybenzoic acid

9-(2-bromo-4-methoxybenzylidene)fluorene

2-bromo-4-methoxy-1-vinylbenzene

2-bromo-4-methoxy-5-nitrobenzaldehyde