1-(2-Fluoropyridin-3-yl)ethanol

Base Information

• Chemical Name: 1-(2-Fluoropyridin-3-yl)ethanol
• CAS No.: 79574-61-1
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.145
• European Community (EC) Number: 846-830-4
• Mol file: 79574-61-1.mol

Synonyms:1-(2-fluoropyridin-3-yl)ethanol;79574-61-1;2-Fluoro-a-methyl-3-pyridinemethanol;1-(2-Fluoro-3-pyridyl)ethanol;MFCD16037359;1-(2-fluoro-3-pyridinyl)ethanol;1-(2-fluoropyridin-3-yl)ethan-1-ol;SCHEMBL3647568;JUYIDKNNTBXRHG-UHFFFAOYSA-N;AKOS023101185;AB90347;(1R)-1-(2-fluoro-3-pyridyl)ethanol;SY240551;CS-0194683;F15555

Chemical Property of 1-(2-Fluoropyridin-3-yl)ethanol

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 141.058992041
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

98%+ ^*data from raw suppliers

1-(2-Fluoropyridin-3-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=C(N=CC=C1)F)O

Technology Process of 1-(2-Fluoropyridin-3-yl)ethanol

There total 1 articles about 1-(2-Fluoropyridin-3-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-fluoropyridine (372-48-5) + acetaldehyde (75-07-0,9002-91-9) → 1-(2-Fluoro-3-pyridyl)ethanol (79574-61-1)

Guidance literature:

2-fluoropyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 5h;

acetaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 21h;

With water; In tetrahydrofuran; hexane;

Reference yield: 86.0%

1-(2-Fluoro-3-pyridyl)ethanol (79574-61-1) → 1-(2-fluoropyridin-3-yl)ethan-1-one (79574-70-2)

Guidance literature:

With pyridine-SO₃ complex; dimethyl sulfoxide; triethylamine; at 0 - 20 ℃; for 20h;

Reference yield:

1-(2-Fluoro-3-pyridyl)ethanol (79574-61-1) → 1-(2-amino-3-pyridinyl)-1-ethanone (65326-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / CrO₃ / acetone / 3 h

2: 90 percent / NH₃ / H₂O / Heating

With chromium(VI) oxide; ammonia; In water; acetone;

DOI:10.1016/S0022-328X(00)80124-2

upstream raw materials:

2-fluoropyridine

acetaldehyde

Downstream raw materials:

1-(2-fluoropyridin-3-yl)ethan-1-one

1-(2-amino-3-pyridinyl)-1-ethanone

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