3-[(5-Bromopyridin-2-yl)carbonyl]dihydrofuran-2(3h)-one

Base Information

Chemical Name:3-[(5-Bromopyridin-2-yl)carbonyl]dihydrofuran-2(3h)-one
CAS No.:77199-10-1
Molecular Formula:C₁₀H₈BrNO₃
Molecular Weight:270.082
Hs Code.:
DSSTox Substance ID:DTXSID101203583
Mol file:77199-10-1.mol

Synonyms:3-(5-bromopyridine-2-carbonyl)oxolan-2-one;3-[(5-bromopyridin-2-yl)carbonyl]dihydrofuran-2(3h)-one;77199-10-1;3-[(5-bromo-2-pyridinyl)carbonyl]dihydro-2(3H)-furanone;SCHEMBL4890246;DTXSID101203583;AC-907/34131040

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Chemical Property of 3-[(5-Bromopyridin-2-yl)carbonyl]dihydrofuran-2(3h)-one

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:268.96876
Heavy Atom Count:15
Complexity:282

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COC(=O)C1C(=O)C2=NC=C(C=C2)Br

Technology Process of 3-[(5-Bromopyridin-2-yl)carbonyl]dihydrofuran-2(3h)-one

There total 3 articles about 3-[(5-Bromopyridin-2-yl)carbonyl]dihydrofuran-2(3h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 96-48-0
4-butanolide

: 77199-09-8
5-bromo-pyridine-2-carboxylic acid ethyl ester

: 77199-10-1
α-<5-bromopicoloyl>-γ-butyrolactone

Guidance literature:: With sodium hydride; In toluene;

Reference yield:

: 3430-13-5
5-bromo-2-methylpyridine

: 77199-10-1
α-<5-bromopicoloyl>-γ-butyrolactone

Guidance literature:: Multi-step reaction with 3 steps

1: KMnO₄, H₂O / 6 h / 100 °C

2: 1.) SOCl₂ / 1.) reflux, 2 h, 2.) toluene, reflux, 2 h

3: 47 percent / NaH / toluene

With potassium permanganate; thionyl chloride; water; sodium hydride; In toluene;

Reference yield:

: 30766-11-1
5-bromoisonicotinic acid

: 77199-10-1
α-<5-bromopicoloyl>-γ-butyrolactone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) SOCl₂ / 1.) reflux, 2 h, 2.) toluene, reflux, 2 h

2: 47 percent / NaH / toluene

With thionyl chloride; sodium hydride; In toluene;