Enzalutamide Impurity I

Base Information

Chemical Name:Enzalutamide Impurity I
CAS No.:915087-16-0
Molecular Formula:C₂₁H₁₇F₃N₄O₂S
Molecular Weight:446.453
Hs Code.:
European Community (EC) Number:857-186-9
UNII:74K9JK886T
ChEMBL ID:CHEMBL1084516
Mol file:915087-16-0.mol

Synonyms:Enzalutamide Impurity I;915087-16-0;Defluoro enzalutamide;74K9JK886T;UNII-74K9JK886T;Defluoro-MDV3100(Defluoro-enzalutamide);Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-N-methyl-;4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-N-methylbenzamide;SCHEMBL1716352;CHEMBL1084516;CS-0163839;Defluoro-MDV 3100 (Defluoro-enzalutamide);4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-N-methylbenzamide? (Enzalutamide Impurity pound(c);4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-N-methylbenzamide;4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-N-methylbenzamide

Suppliers and Price of Enzalutamide Impurity I

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Defluoro-MDV3100(Defluoro-enzalutamide)
10mg
$ 75.00

Total 13 raw suppliers

Chemical Property of Enzalutamide Impurity I

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:446.10243146
Heavy Atom Count:31
Complexity:798

Purity/Quality:

98% ^*data from raw suppliers

Defluoro-MDV3100(Defluoro-enzalutamide) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(C(=O)N(C(=S)N1C2=CC=C(C=C2)C(=O)NC)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
Uses Defluoro-MDV 3100 (Defluoro-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.

Technology Process of Enzalutamide Impurity I

There total 1 articles about Enzalutamide Impurity I which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%