Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib

Base Information

Chemical Name:Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib
CAS No.:910297-70-0
Molecular Formula:C₂₁H₂₁Cl₂N₅O₃S
Molecular Weight:494.401
Hs Code.:
Mol file:910297-70-0.mol

Synonyms:

Suppliers and Price of Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalateDasatinib
2.5mg
$ 180.00

Medical Isotopes, Inc.
Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalateDasatinib
25 mg
$ 2400.00

Total 6 raw suppliers

Chemical Property of Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib

Chemical Property:

Melting Point:>266oC (dec.)
PKA:10.56±0.70(Predicted)
Density:1.428±0.06 g/cm3(Predicted)
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalateDasatinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib is an intermediate in the preparation of Dasatinib metabolite, and used in the treatment of cancers and immune diseases.

Technology Process of Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib

There total 1 articles about Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 910297-69-7
2-(2-aminothiazole-5-carboxamido)-3-chlorobenzyl pivalate

: 910297-70-0
3-chloro-2-(2-(6-chloro-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamido)benzyl pivalate

Guidance literature:: 2,4-dichloro-2-methylpyrimidine; 2-(2-aminothiazole-5-carboxamido)-3-chlorobenzyl pivalate; With sodium t-butanolate; In tetrahydrofuran; at 10 - 18 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃;