(2-PYRROLIDIN-1-YL-2-OXO-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (2-PYRROLIDIN-1-YL-2-OXO-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 883554-96-9
• Molecular Formula: C₁₁H₂₀N₂O₃
• Molecular Weight: 228.291
• Mol file: 883554-96-9.mol

Synonyms:

Chemical Property of (2-PYRROLIDIN-1-YL-2-OXO-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 5.22E-06mmHg at 25°C
• Boiling Point: 381.1±25.0 °C(Predicted)
• PKA: 11.55±0.46(Predicted)
• Density: 1.108±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

1-(Boc-amino-acetyl)-pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-PYRROLIDIN-1-YL-2-OXO-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 3 articles about (2-PYRROLIDIN-1-YL-2-OXO-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

pyrrolidine (123-75-1) + BOC-glycine (4530-20-5) → tert-butyl N-(2-oxo-2-pyrrolidin-1-yl-ethyl)carbamate (883554-96-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1002/cmdc.201800242

Reference yield: 61.0%

→ tert-butyl N-(2-oxo-2-pyrrolidin-1-yl-ethyl)carbamate (883554-96-9)

Guidance literature:

Reference yield:

BOC-glycine (4530-20-5) + 1-(prop-2-ene-1-sulfinyl)pyrrolidine (1532548-78-9) → tert-butyl N-(2-oxo-2-pyrrolidin-1-yl-ethyl)carbamate (883554-96-9)

Guidance literature:

With dmap; In chloroform; at 70 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ol403508

upstream raw materials:

pyrrolidine

BOC-glycine

1-(prop-2-ene-1-sulfinyl)pyrrolidine

Refernces

• 1、 Lenstra, Danny C.,Damen, Eddy,Leenders, Ruben G. G.,Blaauw, Richard H.,Rutjes, Floris P. J. T.,Wegert, Anita,Mecinovi?, Jasmin. "Structure–Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7". . p. 1405 - 1413. Retrieved 2018/07/29.
• 2、 -. "PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES". Paragraph 0249; 0250; 0251. . Retrieved 2016/03/13.