tert-Butyl (2-(thiophen-3-yl)phenyl)carbamate

Base Information

Chemical Name:tert-Butyl (2-(thiophen-3-yl)phenyl)carbamate
CAS No.:886505-35-7
Molecular Formula:C₁₅H₁₇NO₂S
Molecular Weight:275.371
Hs Code.:
DSSTox Substance ID:DTXSID301226280
Mol file:886505-35-7.mol

Synonyms:886505-35-7;tert-Butyl (2-(thiophen-3-yl)phenyl)carbamate;(2-Thiophen-3-yl-phenyl)-carbamic acid tert-butyl ester;DTXSID301226280;tert-Butyl(2-(thiophen-3-yl)phenyl)carbamate;1,1-Dimethylethyl N-[2-(3-thienyl)phenyl]carbamate;(2-thiophen-3-yl-phenyl)-carbamic acid tert-butyl ester

Suppliers and Price of tert-Butyl (2-(thiophen-3-yl)phenyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl(2-(thiophen-3-yl)phenyl)carbamate 97%
1g
$ 664.00

Arctom
tert-Butyl(2-(thiophen-3-yl)phenyl)carbamate
1g
$ 664.00

Total 1 raw suppliers

Chemical Property of tert-Butyl (2-(thiophen-3-yl)phenyl)carbamate

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:275.09799996
Heavy Atom Count:19
Complexity:314

Purity/Quality:: tert-Butyl(2-(thiophen-3-yl)phenyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1=CC=CC=C1C2=CSC=C2

Technology Process of tert-Butyl (2-(thiophen-3-yl)phenyl)carbamate

There total 3 articles about tert-Butyl (2-(thiophen-3-yl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 6165-69-1
Thien-3-ylboronic acid

: 78839-75-5
2-bromo-N-(tert-butoxycarbonyl)aniline

: 886505-35-7
tert-butyl (2-(thiophen-3-yl)phenyl)carbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 80 ℃; Inert atmosphere;
DOI:10.1021/jo502467m

Reference yield:

: 615-36-1
2-bromoaniline

: 886505-35-7
tert-butyl (2-(thiophen-3-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

1.3: Inert atmosphere; Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jo502467m

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 886505-35-7
tert-butyl (2-(thiophen-3-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

1.3: Inert atmosphere; Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jo502467m