1,2,3,5,6,11b-hexahydroimidazo[1,2-d][1,4]benzoxazepine

Base Information

• Chemical Name: 1,2,3,5,6,11b-hexahydroimidazo[1,2-d][1,4]benzoxazepine
• CAS No.: 77123-89-8
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.245
• Mol file: 77123-89-8.mol

Synonyms:

Chemical Property of 1,2,3,5,6,11b-hexahydroimidazo[1,2-d][1,4]benzoxazepine

Chemical Property:

• Vapor Pressure: 0.00221mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,5,6,11b-hexahydroimidazo[1,2-d][1,4]benzoxazepine

There total 3 articles about 1,2,3,5,6,11b-hexahydroimidazo[1,2-d][1,4]benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(2-bromoethoxy)benzaldehyde (60633-78-5) + ethylenediamine (107-15-3,85404-18-8) → 1,2,3,5,6,11b-hexahydroimidazo<1,2-d><1,4>benzoxazepine (77123-89-8)

Guidance literature:

With potassium carbonate; In acetonitrile; Inert atmosphere; Reflux;

DOI:10.3998/ark.5550190.0012.a22

Reference yield:

bissalicyladimino>nickel(II) (38966-31-3) → 2-{[(E)-2-Aziridin-1-yl-ethylimino]-methyl}-phenol (78186-32-0) + 1,2,3,5,6,11b-hexahydroimidazo<1,2-d><1,4>benzoxazepine (77123-89-8)

Guidance literature:

With potassium hydroxide; hydrogen bromide; trisodium Edetate; Multistep reaction; 1.) MeCN, reflux, 1.5 h, 2.) H₂O, room temp., 1 h;

DOI:10.1021/jo00324a043

Reference yield:

potassium cyanide (151-50-8) + bissalicyladimino>nickel(II) (38966-31-3) → 2-{[(E)-2-Aziridin-1-yl-ethylimino]-methyl}-phenol (78186-32-0) + 1,2,3,5,6,11b-hexahydroimidazo<1,2-d><1,4>benzoxazepine (77123-89-8) + 4-(2-{[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-amino}-ethyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine-5-carbonitrile (77123-90-1)

Guidance literature:

With hydrogen bromide; Multistep reaction; 1.) MeCN, reflux, 1.5 h, 2.) CHCl₃, H₂O, 1 h;

DOI:10.1021/jo00324a043

upstream raw materials:

potassium cyanide

bissalicyladimino>nickel(II)

2-(2-bromoethoxy)benzaldehyde

ethylenediamine

Refernces

• 1、 Levan, Keith R.,Root, Charles A.. "Isolation and Characterisation of 1,2,3,5,6,11b-Hexahydroimidazobenzoxazepine from an Aziridine Ligand Reaction". . p. 2404 - 2406. Retrieved 2007/10/02.