60633-78-5Relevant academic research and scientific papers
Selective detection of Hg(II) with benzothiazole-based fluorescent organic cation and the resultant complex as a ratiometric sensor for bromide in water
Singh, Amanpreet,Singh, Ajnesh,Singh, Narinder,Jang, Doo Ok
, p. 3535 - 3541 (2016)
A benzothiazole-based receptor conjugated with an imidazolium cation, receptor N1, was synthesized. Receptor N1 is capable of selectively binding Hg(II) in the presence of other metal ions in water, with a large enhancement in fluorescence intensity at 38
New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies
Sava, Alexandru,Buron, Frederic,Routier, Sylvain,Panainte, Alina,Bibire, Nela,Profire, Lenu?a
, (2021/05/10)
In this study we present design and synthesis of nineteen new nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold (NO-IND-TZDs) (6a–s), as a new safer and efficient multi-targets strategy for inflammatory diseases. The che
Design, synthesis, in silico and in vitro studies for new nitric oxide‐releasing indomethacin derivatives with 1,3,4‐oxadiazole‐2‐thiol scaffold
Sava, Alexandru,Buron, Frederic,Routier, Sylvain,Panainte, Alina,Bibire, Nela,Constantin, Sandra M?d?lina,Lupa?cu, Florentina Geanina,Foc?a, Alin Viorel,Profire, Lenu?a
, (2021/07/07)
Starting from indomethacin (IND), one of the most prescribed non‐steroidal anti‐inflammatory drugs (NSAIDs), new nitric oxide‐releasing indomethacin derivatives with 1,3,4‐oxadiazole‐ 2‐thiol scaffold (NO‐IND‐OXDs, 8a‐p) have been developed as a safer and
Crystal structure analysis and quantum chemical study of two macrocyclic compounds
Maragatham,Prabhakaran,Rajakumar,Lakshmi
, (2019/12/23)
The synthesis of new organic macrocyclic nonlinear optical materials with good performance has taken the prime focus of research due to the unlimited design possibilities. Two macrocyclic structures, confirmed by 1H, 13C NMR and FT-IR, namely spiro pyrrolidine grafted methyl macrocycle C28H26N2O3 and 1,2,3 triazole bridged pyrrolidine grafted chloro macrocycle C29H27Cl1N4O30.5(H2O) are analysed by single crystal X-ray diffraction method. The UV–Vis spectra of the two compounds show that these crystals are transparent in the entire visible region. The global reactivity descriptors such as ionization potential, electron affinity, electronegativity, chemical hardness, chemical potential, chemical softness, electrophilicity index and nonlinear optical parameters such as dipole moment (μ) and static second order hyperpolarizability (γ) are determined in gas phase at the molecular level by semiempirical quantum chemical method with the coordinates obtained from X-ray diffraction as the starting geometry. In addition, the bioactivity scores were calculated from the chemical skeleton.
Iron-catalyzed protodehalogenation of alkyl and aryl halides using hydrosilanes
Pilli, Ramadevi,Balakrishnan, Venkadesh,Chandrasekaran, Revathi,Rasappan, Ramesh
supporting information, p. 1749 - 1753 (2019/02/20)
A simple and efficient iron-catalyzed protodehalogenation of alkyl and aryl halides using phenylhydrosilane is disclosed. The reaction utilizes FeCl3 without the requirement of ligands. Unactivated alkyl and aryl halides were successfully reduced in good yields; sterically hindered tertiary halides were also reduced including the less reactive chlorides. The scalability of this methodology was demonstrated by a gram-scale synthesis with a catalyst loading as low as 0.5 mol%. Notably, disproportionation of phenylsilane leads to diphenylsilane that further reduces the halides. Preliminary mechanistic studies revealed a non-radical pathway and the source of hydrogen is PhSiH3via deuterium labeling studies. Our methodology represents simplicity and provides a good alternative to typical tin, aluminum and boron hydride reagents.
A nanomolar detection of mercury(II) ion by a chemodosimetric rhodamine-based sensor in an aqueous medium: Potential applications in real water samples and as paper strips
Patil, Sagar K.,Das, Dipanwita
, p. 44 - 51 (2018/11/24)
A new promising rhodamine based colorimetric and fluorometric chemosensor, RDV has been designed and synthesized for specific detection of Hg2+ ion. It acts as highly selective “turn-on” fluorescent chemosensor for Hg2+ ion without i
Ligand-controlled gold-catalyzed cycloisomerization of 1,: N -enyne esters toward synthesis of dihydronaphthalene
Thummanapelli, Sravan K.,Hosseyni, Seyedmorteza,Su, Yijin,Akhmedov, Novruz G.,Shi, Xiaodong
supporting information, p. 7687 - 7690 (2016/07/06)
We describe herein a gold-catalyzed rearrangement of propargyl esters followed by allene-ene cyclization to afford substituted bicyclic [4.4.0] dihydronaphthalene compounds. This method is also applied to vinylethers and vinylamines of 1,7-enyne esters to
A Facile and Efficient Synthesis of Six-Membered Enol Carbocyclic Compounds
Yang, De-Suo,Ke, Sen,Fan, Ming-Jin,Zhu, Hai-Tao,Wang, Xiao-Ling,Guan, Zheng-Hui
supporting information, p. 2826 - 2830 (2015/12/18)
A facile and efficient method for the synthesis of six-membered enol carbocyclic compounds was realized by intermolecular cyclization reaction of 3-aryllidenepentane-2,4-diones with t-BuOK in CH2Cl2. The reaction is conducted under m
Origins of initiation rate differences in ruthenium olefin metathesis catalysts containing chelating benzylidenes
Engle, Keary M.,Lu, Gang,Luo, Shao-Xiong,Henling, Lawrence M.,Takase, Michael K.,Liu, Peng,Houk,Grubbs, Robert H.
supporting information, p. 5782 - 5792 (2015/05/20)
A series of second-generation ruthenium olefin metathesis catalysts was investigated using a combination of reaction kinetics, X-ray crystallography, NMR spectroscopy, and DFT calculations in order to determine the relationship between the structure of the chelating o-alkoxybenzylidene and the observed initiation rate. Included in this series were previously reported catalysts containing a variety of benzylidene modifications as well as four new catalysts containing cyclopropoxy, neopentyloxy, 1-adamantyloxy, and 2-adamantyloxy groups. The initiation rates of this series of catalysts were determined using a UV/vis assay. All four new catalysts were observed to be faster-initiating than the corresponding isopropoxy control, and the 2-adamantyloxy catalyst was found to be among the fastest-initiating Hoveyda-type catalysts reported to date. Analysis of the X-ray crystal structures and computed energy-minimized structures of these catalysts revealed no correlation between the Ru-O bond length and Ru-O bond strength. On the other hand, the initiation rate was found to correlate strongly with the computed Ru-O bond strength. This latter finding enables both the rationalization and prediction of catalyst initiation through the calculation of a single thermodynamic parameter in which no assumptions about the mechanism of the initiation step are made.
A selective and sensitive phenanthroimidazole-based "reactive" ratiometric sensor for recognition of Hg2+ ions in aqueous solution
Yan, Yuanyuan,Zhang, Rui,Yu, Xiang,Xu, Hui
, p. 1676 - 1680 (2015/01/09)
Based on specific reactivity of the vinyloxy group to Hg2+ ions, a new ratiometric phenanthroimidazole-based fluorescent sensor, 2-(2-(vinyloxy)phenyl)-1H-phenanthro[9,10-d]imidazole, is prepared. The selectivity of the probe toward Hg2+/
