2-Fluoro-5-phenylpyridine

Base Information

• Chemical Name: 2-Fluoro-5-phenylpyridine
• CAS No.: 928822-80-4
• Molecular Formula: C₁₁H₈FN
• Molecular Weight: 173.19
• Mol file: 928822-80-4.mol

Synonyms:

Chemical Property of 2-Fluoro-5-phenylpyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-5-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-Fluoro-5-phenylpyridine

There total 9 articles about 2-Fluoro-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-2-fluoropyridine (766-11-0) + phenylboronic acid (98-80-6) → 2-fluoro-5-phenyl-pyridine (928822-80-4)

Guidance literature:

With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 90 ℃; for 2h;

Reference yield: 90.0%

6-fluoropyridin-3-yl fluorosulfate + phenylboronic acid (98-80-6) → 2-fluoro-5-phenyl-pyridine (928822-80-4)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In ethanol; water; at 35 ℃; for 3h; chemoselective reaction;

DOI:10.1002/chem.201600167

Reference yield: 89.0%

2-fluoro-5-chloropyridine (1480-65-5) + phenylboronic acid (98-80-6) → 2-fluoro-5-phenyl-pyridine (928822-80-4)

Guidance literature:

With 4,5-dimethyl-3-(2-phenoxyphenyl)-1-(2,4,6-trimethylbenzyl)imidazolium chloride; palladium diacetate; caesium carbonate; In 1,4-dioxane; at 90 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol4010189

upstream raw materials:

5-bromo-2-fluoropyridine

phenylboronic acid

2-fluoro-5-chloropyridine

phenyltrifluorosilane

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