N-Fmoc-1,6-diaminohexane HCl

Base Information

• Chemical Name: N-Fmoc-1,6-diaminohexane HCl
• CAS No.: 945923-91-1
• Molecular Formula: C₂₁H₂₆N₂O₂*ClH
• Molecular Weight: 374.911
• Hs Code.: 2929900090
• Mol file: 945923-91-1.mol

Synonyms:

Chemical Property of N-Fmoc-1,6-diaminohexane HCl

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

Fmoc-Hmdhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Fmoc-Hmd HCl

Technology Process of N-Fmoc-1,6-diaminohexane HCl

There total 2 articles about N-Fmoc-1,6-diaminohexane HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

Ν1-(9-fluorenylmethyloxycarbonyl)-1,6-hexamethylenediamine (166410-37-3) → 9H-fluoren-9-ylmethyl N-(6-aminohexyl)carbamate hydrochloride (945923-91-1)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane;

DOI:10.1021/ol503343b

Reference yield:

1,6-Hexanediamine (124-09-4) + 9-fluorenylmethyl N-succinimidyl carbonate (102774-86-7) → 9H-fluoren-9-ylmethyl N-(6-aminohexyl)carbamate hydrochloride (945923-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.01 h / 0 °C / Flow reactor

2: hydrogenchloride / methanol; dichloromethane

With hydrogenchloride; In methanol; dichloromethane;

DOI:10.1021/ol503343b

Reference yield:

9H-fluoren-9-ylmethyl N-(6-aminohexyl)carbamate hydrochloride (945923-91-1) + cyclopent-3-ene-1-carboxylic acid chloride (3744-80-7) → 9H-fluoren-9-ylmethyl{6-[(3-cyclopenten-1-ylcarbonyl)amino]hexyl}carbamate (942412-24-0)

Guidance literature:

With pyridine; In dichloromethane; for 5h;

DOI:10.1039/b701953j

upstream raw materials:

1,6-Hexanediamine

9-fluorenylmethyl N-succinimidyl carbonate

Ν¹-(9-fluorenylmethyloxycarbonyl)-1,6-hexamethylenediamine

Downstream raw materials:

9H-fluoren-9-ylmethyl{6-[(3-cyclopenten-1-ylcarbonyl)amino]hexyl}carbamate