BCX-4161

Base Information

Chemical Name:BCX-4161
CAS No.:918407-35-9
Molecular Formula:C₂₈H₂₇N₅O₅
Molecular Weight:513.553
Hs Code.:
Mol file:918407-35-9.mol

Synonyms:

Suppliers and Price of BCX-4161

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinicacid
100mg
$ 1617.20

Alichem
3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinicacid
25mg
$ 609.56

Total 5 raw suppliers

Chemical Property of BCX-4161

Chemical Property:

PKA:2.99±0.36(Predicted)
Density:1.38±0.1 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of BCX-4161

There total 15 articles about BCX-4161 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.1%

: methyl 3-[2-(4-carbamimidoylphenylcarbamoyl)-5-methoxy-4-vinylphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylate methanesulfonate

: 64-19-7,77671-22-8
acetic acid

: 918407-35-9
3-[2-(4-carbamimidoylphenylcarbamoyl)-5- methoxy-4-vinylphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylic acid

Guidance literature:: methyl 3-[2-(4-carbamimidoylphenylcarbamoyl)-5-methoxy-4-vinylphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylate methanesulfonate; With sodium hydroxide; In acetonitrile; at 0 - 5 ℃; for 2.5h; Large scale;

acetic acid; In water; at 20 ℃; for 0.416667h; Large scale;

Reference yield:

: 3430-31-7
3-bromo-2,6-dimethylpyridine

: 918407-35-9
3-[2-(4-carbamimidoylphenylcarbamoyl)-5- methoxy-4-vinylphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium permanganate / water / 14 h / 90 °C / Heating; Large scale

2.1: sulfuric acid / 5.3 h / 65 °C / Heating; Large scale

3.1: 17 h / 65 °C / Heating; Large scale

4.1: sodium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / 6.5 h / Reflux; Inert atmosphere; Large scale

5.1: 1.3 h / -5 °C / Large scale

6.1: bis-triphenylphosphine-palladium(II) chloride; potassium hydrogencarbonate / Large scale

7.1: 2-methyl-but-2-ene; sodium chlorite / acetonitrile; tert-butyl alcohol / 4.5 h / 0 - 7 °C / Large scale

8.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / isopropyl alcohol / 13 h / 20 °C / Large scale

8.2: Large scale

9.1: sodium hydroxide / acetonitrile / 2.5 h / 0 - 5 °C / Large scale

9.2: 0.42 h / 20 °C / Large scale

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; potassium permanganate; 2-methyl-but-2-ene; sulfuric acid; sodium carbonate; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; In water; isopropyl alcohol; acetonitrile; tert-butyl alcohol;

Reference yield:

: 5-hydroxy-4-methoxy-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl) benzaldehyde

: 918407-35-9
3-[2-(4-carbamimidoylphenylcarbamoyl)-5- methoxy-4-vinylphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / 6.5 h / Reflux; Inert atmosphere; Large scale

2.1: 1.3 h / -5 °C / Large scale

3.1: bis-triphenylphosphine-palladium(II) chloride; potassium hydrogencarbonate / Large scale

4.1: 2-methyl-but-2-ene; sodium chlorite / acetonitrile; tert-butyl alcohol / 4.5 h / 0 - 7 °C / Large scale

5.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / isopropyl alcohol / 13 h / 20 °C / Large scale

5.2: Large scale

6.1: sodium hydroxide / acetonitrile / 2.5 h / 0 - 5 °C / Large scale

6.2: 0.42 h / 20 °C / Large scale

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; 2-methyl-but-2-ene; sodium carbonate; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; In isopropyl alcohol; acetonitrile; tert-butyl alcohol;