(S)-2-methyltetrahydropyran-4-ol

Base Information

• Chemical Name: (S)-2-methyltetrahydropyran-4-ol
• CAS No.: 1202377-97-6
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.16
• Mol file: 1202377-97-6.mol

Synonyms:

Chemical Property of (S)-2-methyltetrahydropyran-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-methyltetrahydropyran-4-ol

There total 2 articles about (S)-2-methyltetrahydropyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyltetrahydro-4H-pyran-4-one (1193-20-0) + isopropyl alcohol (67-63-0,8013-70-5) → (S)-2-methyltetrahydropyran-4-ol (1202377-97-6) + (2R)-2-methyltetrahydro-4H-pyran-4-one (82110-22-3) + acetone (67-64-1)

Guidance literature:

2-methyltetrahydro-4H-pyran-4-one; isopropyl alcohol; With sodium dihydrogenphosphate dihydrate; sodium phosphate dibasic dodecahydrate; β-nicotinamide adenine dinucleotide, reduced dipotassium salt; In water; at 20 - 25 ℃; pH=6.5 - 7.5; Resolution of racemate; Industrial scale; Green chemistry; Enzymatic reaction;

With alcohol dehydrogenase ADH-097 from c-LEcta; In water; at 10 - 27 ℃; Concentration; Reagent/catalyst; stereospecific reaction; Catalytic behavior; Resolution of racemate; Enzymatic reaction; Industrial scale; Green chemistry;

DOI:10.1021/acs.oprd.0c00557

Reference yield:

(2S)-2-methyl-2,3-dihydropyran-4-one (190912-15-3) → (S)-2-methyltetrahydropyran-4-ol (1202377-97-6) + (S)-2-methyl-3,4,5,6-tetrahydro-2H-pyran-4-one (82110-21-2)

Guidance literature:

With palladium/alumina; hydrogen; In toluene; at 50 ℃; for 3h; under 22502.3 Torr;

DOI:10.1021/op900163a

upstream raw materials:

(2S)-2-methyl-2,3-dihydropyran-4-one

2-methyltetrahydro-4H-pyran-4-one

isopropyl alcohol

Refernces

• 1、 Anderson, Kevin R.,Atkinson, Stephanie L. G.,Fujiwara, Takahiro,Giles, Melvyn E.,Matsumoto, Takaji,Merifield, Eric,Singleton, John T.,Saito, Takao,Sotoguchi, Tsukasa,Tornos, James A.,Way, Edward L.. "Routes for the synthesis of (2S)-2-methyltetrahydropyran-4-one from simple optically pure building blocks". . p. 58 - 71. Retrieved 2010.