1193-20-0

Basic information

• Product Name: 2-methyl-tetrahydropyran-4-one
• Synonyms: 2-methyl-tetrahydropyran-4-one;2-Methyloxan-4-one;2-Methyldihydro-2H-pyran-4(3H)-one;tetrahydro-2-methyl-4H-Pyran-4-one;2-methyltetrahydro-4H-pyran-4-one;EOS-62013
• CAS NO: 1193-20-0
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.1424
• Mol File: 1193-20-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 174.9°C at 760 mmHg
• Flash Point: 63.5°C
• Appearance: /
• Density: 1.001g/cm³
• Vapor Pressure: 1.18mmHg at 25°C
• Refractive Index: 1.43
• CAS DataBase Reference: 2-methyl-tetrahydropyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-tetrahydropyran-4-one(1193-20-0)
• EPA Substance Registry System: 2-methyl-tetrahydropyran-4-one(1193-20-0)

Safety Data

• Hazardous Substances Data: 1193-20-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 3494, 1994 DOI: 10.1021/jo00091a048

InChI:InChI=1/C6H10O2/c1-5-4-6(7)2-3-8-5/h5H,2-4H2,1H3

Upstream product

• 89791-47-9 (2S,4S)-4-hydroxy-2-methyltetrahydropyran 
• 821-08-9 hexa-1,5-dien-3-yne 
• 7664-93-9 sulfuric acid 
• 19185-89-8 2-methyl-2,3-dihydro-4H-pyran-4-one 
• 155206-69-2 3-Ethoxyhexa-3,5-dien-1-ol 
• 33747-08-9 cis-2-methyltetrahydro-2H-pyran-4-ol 

Downstream Products

• 33747-08-9 (2R,4R)-2-methyltetrahydro-2H-pyran-4-ol 
• 82110-17-6 trans-2-Methyl-tetrahydropyran-4-ol 
• 82110-13-2 (2S,4S)-4-hydroxy-2-methyl-3,4,5,6-tetrahydro-2H-pyran 
• 82110-21-2 (S)-2-methyl-3,4,5,6-tetrahydro-2H-pyran-4-one 
• 55230-32-5 trans-2-methyltetrahydropyran-4-ol 
• 33747-08-9 cis-2-methyltetrahydro-2H-pyran-4-ol 
• 13669-32-4 (+-)-1,2-dimethylpiperidine-4-one 
• 693247-77-7 C₂₄H₃₂F₆N₂O₂ 
• 89584-06-5 2-methyltetrahydro-2H-pyran-4-amine 
• 1202377-97-6 (S)-2-methyltetrahydropyran-4-ol 
• 82110-22-3 (2R)-2-methyltetrahydro-4H-pyran-4-one 
• 67-64-1 acetone 

Relevant articles and documents

Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction

A biocatalytic cascade to produce tert-butyl ((2R,4R)-2-methyltetrahydro-2H-pyran-4-yl)carbamate 6 has been demonstrated at the multikilogram scale. In this reaction, a racemic ketone is resolved by reducing the undesired ketone using a ketone reductase (KRED). The reduction is stereospecific for the 2-position of substrate (2S)-ketone leaving the (2R)-ketone unreacted. After the (2S)-ketone has been depleted, a transaminase is added to catalyze the enantioselective transamination of the ketone, resulting in formation of the (2R, 4R)-amine 6. The product is recovered from the aqueous reaction after Boc protection.

CYCLIC SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES

The present invention provides novel cyclic substituted imidazo[4,5- c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof, wherein R1, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS

The present invention relates to novel 4- (heterocycloalkyl) benzene- 1,3-diol compounds corresponding to general formula (I) below: to the compositions containing same, to the process for the preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders