3,5-difluoro-2-methylphenol

Base Information

• Chemical Name: 3,5-difluoro-2-methylphenol
• CAS No.: 900512-26-7
• Molecular Formula: C₇H₆F₂O
• Molecular Weight: 144.121
• Mol file: 900512-26-7.mol

Synonyms:

Chemical Property of 3,5-difluoro-2-methylphenol

Chemical Property:

Purity/Quality:

3,5-difluoro-2-methylphenol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-difluoro-2-methylphenol

There total 1 articles about 3,5-difluoro-2-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(acetyloxy)-4,6-difluorobenzyl acetate (900512-25-6) → 3,5-difluoro-2-methyl-phenol (900512-26-7)

Guidance literature:

2-(acetyloxy)-4,6-difluorobenzyl acetate; With sodium tetrahydroborate; In 1,2-dimethoxyethane; at 45 ℃; for 18h;

With water; ammonium chloride; In 1,2-dimethoxyethane; Cooling with acetone-dry ice;

Reference yield:

3,5-difluoro-2-methyl-phenol (900512-26-7) + 4-(2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester (1175014-69-3) → C25H22F2N4O2 (1175013-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / 1-methyl-pyrrolidin-2-one / 20 - 140 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 20 °C

With sodium hydride; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;

DOI:10.1016/j.bmcl.2011.06.114

Reference yield:

3,5-difluoro-2-methyl-phenol (900512-26-7) + 4-(2-chloro-1-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester (1175015-14-1) → C30H30F2N4O4

Guidance literature:

With 1-methyl-pyrrolidin-2-one; sodium hydride; at 20 - 140 ℃; Microwave irradiation;

DOI:10.1016/j.bmcl.2011.06.112

upstream raw materials:

2-(acetyloxy)-4,6-difluorobenzyl acetate

Downstream raw materials:

C₂₅H₂₂F₂N₄O₂

Refernces