N-L-leucyl-1-aminoethanephosphonic acid

Base Information

• Chemical Name: N-L-leucyl-1-aminoethanephosphonic acid
• CAS No.: 60668-50-0
• Molecular Formula: C₈H₁₉N₂O₄P
• Molecular Weight: 238.224
• Mol file: 60668-50-0.mol

Synonyms:

Chemical Property of N-L-leucyl-1-aminoethanephosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-L-leucyl-1-aminoethanephosphonic acid

There total 7 articles about N-L-leucyl-1-aminoethanephosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phosphonic acid dimethyl ester (82818-50-6) → N-L-leucyl-1-aminoethanephosphonic acid (60668-50-0,82818-32-4,84340-65-8)

Guidance literature:

With hydrogen bromide; In acetic acid; Yield given; Ambient temperature; overnight;

DOI:10.1055/s-1982-29818

Reference yield:

Z-Leu-OH (2018-66-8) → N-L-leucyl-1-aminoethanephosphonic acid (60668-50-0,82818-32-4,84340-65-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Triethylamine, ethyl carbonochloridate / 1.) CHCl₃, - 5 deg C, 20 min, 2.) reflux, 30 min

2: KF*2H₂O, 18-crown-6 / methanol / 0.08 h / Heating

3: HBr / acetic acid / Ambient temperature; overnight

With potassium fluoride; 18-crown-6 ether; hydrogen bromide; chloroformic acid ethyl ester; triethylamine; In methanol; acetic acid;

DOI:10.1055/s-1982-29818

Reference yield:

[1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phosphonic acid diphenyl ester (82818-40-4,126306-94-3,126306-95-4) → N-L-leucyl-1-aminoethanephosphonic acid (60668-50-0,82818-32-4,84340-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: KF*2H₂O, 18-crown-6 / methanol / 0.08 h / Heating

2: HBr / acetic acid / Ambient temperature; overnight

With potassium fluoride; 18-crown-6 ether; hydrogen bromide; In methanol; acetic acid;

DOI:10.1055/s-1982-29818

upstream raw materials:

[1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phosphonic acid dimethyl ester

N-tert-butoxycarbonyl-L-leucine

N-formyl-L-leucine

Z-Leu-OH