(R)-[1-(diphenylphosphanyl)ethyl]ferrocene

Base Information

• Chemical Name: (R)-[1-(diphenylphosphanyl)ethyl]ferrocene
• CAS No.: 178388-23-3
• Molecular Formula: C₂₄H₂₃FeP
• Molecular Weight: 398.267
• Mol file: 178388-23-3.mol

Synonyms:

Chemical Property of (R)-[1-(diphenylphosphanyl)ethyl]ferrocene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-[1-(diphenylphosphanyl)ethyl]ferrocene

There total 2 articles about (R)-[1-(diphenylphosphanyl)ethyl]ferrocene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(R,Sp)-1-bromo-2-[1-(diphenylphosphanyl)ethyl]ferrocene + carbon dioxide (124-38-9,18923-20-1) → (R)-[1-(diphenylphosphanyl)ethyl]ferrocene (178388-23-3) + (R,Rp)-2-[1-(diphenylphosphanyl)ethyl]ferrocenecarboxylicacid

Guidance literature:

With BuLi; In tetrahydrofuran; hexane; under Ar with exclusion of direct daylight, LiBu (5.3 mmol) in hexanes added dropwise with stirring to soln. of Fe compd. (4 mmol) in THF at -78°C for 1 h, excess solid CO2 added, stirred at room temp. overnight; diluted with water and Et2O, washed satd. NaCl soln., org. layer septd.,dried (MgSO4), evapd., chromd. (SiO2, CH2Cl2/MeOH=20/1);

DOI:10.1002/ejic.200700093

Reference yield:

(R)-N,N-dimethyl-1-ferrocenylethylamine (31886-58-5) + diphenylphosphane (829-85-6) → (R)-[1-(diphenylphosphanyl)ethyl]ferrocene (178388-23-3)

Guidance literature:

With acetic anhydride; In acetic acid; treated with excess acetic acid anhydride, reacted with diarylphosphine;

DOI:10.1039/b007781j

upstream raw materials:

(R)-N,N-dimethyl-1-ferrocenylethylamine

diphenylphosphane

carbon dioxide