N-(Benzyloxy)-3-cyclopentyl-2-(hydroxymethyl)hexanamide

Base Information

Chemical Name:N-(Benzyloxy)-3-cyclopentyl-2-(hydroxymethyl)hexanamide
CAS No.:301685-10-9
Molecular Formula:C16H23 N O3
Molecular Weight:277.364
Hs Code.:
DSSTox Substance ID:DTXSID80699431
Mol file:301685-10-9.mol

Synonyms:301685-10-9;DTXSID80699431;A820234;N-benzyloxy-3-cyclopentyl-2-(hydroxymethyl)hexanamide;N-(Benzyloxy)-3-cyclopentyl-2-(hydroxymethyl)hexanamide;3-cyclopentyl-2-(hydroxymethyl)-N-phenylmethoxyhexanamide

Suppliers and Price of N-(Benzyloxy)-3-cyclopentyl-2-(hydroxymethyl)hexanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2R)-2-(HYDROXYMETHYL)-3-(CYCLOPENTYL)-N-(PHENYLMETHOXY)HEXANAMIDE 95.00%
5MG
$ 503.34

Total 14 raw suppliers

Chemical Property of N-(Benzyloxy)-3-cyclopentyl-2-(hydroxymethyl)hexanamide

Chemical Property:

PSA：58.56000
LogP:3.84030
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:319.21474379
Heavy Atom Count:23
Complexity:336

Purity/Quality:

99% ^*data from raw suppliers

(2R)-2-(HYDROXYMETHYL)-3-(CYCLOPENTYL)-N-(PHENYLMETHOXY)HEXANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC(C1CCCC1)C(CO)C(=O)NOCC2=CC=CC=C2

Technology Process of N-(Benzyloxy)-3-cyclopentyl-2-(hydroxymethyl)hexanamide

There total 6 articles about N-(Benzyloxy)-3-cyclopentyl-2-(hydroxymethyl)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 301685-09-6
(2R)-3-cyclopentyl-2-(hydroxymethyl)propanoic acid

: 622-33-3
N-benzyloxyamine

: 301685-10-9
(2R)-3-cyclopentyl-2-(hydroxymethyl)-N-[(phenylmethyl)oxy]propanamide

Guidance literature:: With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; at 20 ℃; for 2.5h; pH=4.5;

Reference yield: 65.0%

: 301685-09-6
(2R)-3-cyclopentyl-2-(hydroxymethyl)propanoic acid

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 301685-10-9
(2R)-3-cyclopentyl-2-(hydroxymethyl)-N-[(phenylmethyl)oxy]propanamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

: (4S)-4-benzyl-3-(3-cyclopentylpropanoyl)-1,3-oxazolidin-2-one

: 301685-10-9
(2R)-3-cyclopentyl-2-(hydroxymethyl)-N-[(phenylmethyl)oxy]propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C

1.3: 3.5 h / 0 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol; N,N-dimethyl-formamide / 84 h / 20 °C / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide monohydrate; water / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; dihydrogen peroxide; titanium tetrachloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;