Ethyl 2-amino-4-fluoro-4-methylpentanoate

Base Information

Chemical Name:Ethyl 2-amino-4-fluoro-4-methylpentanoate
CAS No.:885498-60-2
Molecular Formula:C₈H₁₆FNO₂
Molecular Weight:177.219
Hs Code.:
European Community (EC) Number:810-307-9
DSSTox Substance ID:DTXSID201310575

Synonyms:Ethyl 2-amino-4-fluoro-4-methylpentanoate;885498-60-2;Leucine, 4-fluoro-, ethyl ester;ethyl 4-fluoro-L-leucinate;(S)-4-Fluoroleucine ethyl ester;4-FLUOROLEUCINE ETHYL ESTER;(S)-ethyl 2-aMino-4-fluoro-4-Methylpentanoate;SCHEMBL1066669;L-4-fluoro-leucine ethyl ester;DTXSID201310575;BCP11795;CS-M3103;MFCD22124918;AKOS037650469;SB17948;CS-14855;Ethyl2-amino-4-fluoro-4-methylpentanoate;PD196070;SY258487;EN300-1297290

Suppliers and Price of Ethyl 2-amino-4-fluoro-4-methylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Leucine,4-fluoro-,ethylester
5g
$ 1500.00

ChemScene
Leucine,4-fluoro-,ethylester
1g
$ 650.00

Total 2 raw suppliers

Chemical Property of Ethyl 2-amino-4-fluoro-4-methylpentanoate

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:177.11650692
Heavy Atom Count:12
Complexity:159

Purity/Quality:

99% ^*data from raw suppliers

Leucine,4-fluoro-,ethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(CC(C)(C)F)N

Technology Process of Ethyl 2-amino-4-fluoro-4-methylpentanoate

There total 11 articles about Ethyl 2-amino-4-fluoro-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: (S)-ethyl 2-amino-4-methylpent-4-enoate (+)-camphorsulfonic acid salt

: 156047-39-1,885498-60-2
ethyl (2S)-2-amino-4-fluoro-4-methylpentanoate

Guidance literature:: (S)-ethyl 2-amino-4-methylpent-4-enoate (+)-camphorsulfonic acid salt; With urea hydrogen fluoride; In water; at 0 - 20 ℃; for 3h; Inert atmosphere;

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; trifluoroacetic acid; In tert-butyl methyl ether; water; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: ethyl 2-(benzylamino)-4-fluoro-4-methylpentanoate

: 885498-60-2
ethyl (2R)-2-amino-4-fluoro-4-methylpentanoate

: 156047-39-1,885498-60-2
ethyl (2S)-2-amino-4-fluoro-4-methylpentanoate

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; at 20 ℃; for 16h; under 2792.6 Torr; Title compound not separated from byproducts;
DOI:10.1055/s-2005-923593

Reference yield:

: ethyl 2-(benzylamino)-4-fluoro-4-methylpentanoate

: 885498-60-2
ethyl (2R)-2-amino-4-fluoro-4-methylpentanoate

: 156047-39-1,885498-60-2
ethyl (2S)-2-amino-4-fluoro-4-methylpentanoate

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; at 20 ℃; for 16h; under 2792.6 Torr; Title compound not separated from byproducts;
DOI:10.1055/s-2005-923593