ethyl 4-fluoro-4-Methyl-2-pent-4-enaMidopentanoate

Base Information

Chemical Name:ethyl 4-fluoro-4-Methyl-2-pent-4-enaMidopentanoate
CAS No.:848949-92-8
Molecular Formula:C13H22FNO3
Molecular Weight:259.31700
Hs Code.:
Mol file:848949-92-8.mol

Synonyms:

Suppliers and Price of ethyl 4-fluoro-4-Methyl-2-pent-4-enaMidopentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
L-Leucine,4-fluoro-N-(1-oxo-4-penten-1-yl)-,ethylester
25mg
$ 330.00

Total 3 raw suppliers

Chemical Property of ethyl 4-fluoro-4-Methyl-2-pent-4-enaMidopentanoate

Chemical Property:

PSA：55.40000
LogP:2.52960

Purity/Quality:

≥95% ^*data from raw suppliers

L-Leucine,4-fluoro-N-(1-oxo-4-penten-1-yl)-,ethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-fluoro-4-Methyl-2-pent-4-enaMidopentanoate

There total 8 articles about ethyl 4-fluoro-4-Methyl-2-pent-4-enaMidopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 848949-90-6
2-but-3-enyl-4-(2-fluoro-2-methyl-propyl)-4H-oxazol-5-one

: 848949-92-8
(S)-4-Fluoro-4-methyl-2-pent-4-enoylamino-pentanoic acid ethyl ester

Guidance literature:: With novozyme 435; triethylamine; In tert-butyl methyl ether; at 20 ℃; for 3 - 6h;

Reference yield:

: 64-17-5
ethanol

: 848949-90-6
2-but-3-enyl-4-(2-fluoro-2-methyl-propyl)-4H-oxazol-5-one

: (R)-4-Fluoro-4-methyl-2-pent-4-enoylamino-pentanoic acid ethyl ester

: 848949-92-8
(S)-4-Fluoro-4-methyl-2-pent-4-enoylamino-pentanoic acid ethyl ester

Guidance literature:: With novozyme-435; triethylamine; In various solvent(s); at 20 ℃; for 4h; Title compound not separated from byproducts; Enzymatic reaction;
DOI:10.1021/jo047918j

Reference yield:

: 848949-86-0
ethyl-2-(diphenylmethyleneamino)-4-fluoro-4-methylpentanoate

: 848949-92-8
(S)-4-Fluoro-4-methyl-2-pent-4-enoylamino-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: HCl / H₂O; various solvent(s) / 12 h / 20 °C

1.2: NaHCO₃ / various solvent(s) / 0.5 h / 20 °C

1.3: 96 percent / NaOH / tetrahydrofuran; H₂O; various solvent(s) / 4 h / 20 °C

2.1: EDCI / CH₂Cl₂ / 2 h / 20 °C

3.1: Novozyme-435; Et₃N / various solvent(s) / 4 h / 20 °C / Enzymatic reaction

With hydrogenchloride; novozyme-435; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; 1.2: Schotten-Baumman rection;
DOI:10.1021/jo047918j