Leucine, N-(diphenylmethylene)-4-fluoro-, ethyl ester

Base Information

Chemical Name:Leucine, N-(diphenylmethylene)-4-fluoro-, ethyl ester
CAS No.:848949-86-0
Molecular Formula:C21H24FNO2
Molecular Weight:341.425
Hs Code.:
European Community (EC) Number:639-769-8

Synonyms:Leucine, N-(diphenylmethylene)-4-fluoro-, ethyl ester;848949-86-0;SCHEMBL1068082

Suppliers and Price of Leucine, N-(diphenylmethylene)-4-fluoro-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Leucine, N-(diphenylmethylene)-4-fluoro-, ethyl ester

Chemical Property:

XLogP3:5.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:341.17910717
Heavy Atom Count:25
Complexity:429

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(CC(C)(C)F)N=C(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Leucine, N-(diphenylmethylene)-4-fluoro-, ethyl ester

There total 1 articles about Leucine, N-(diphenylmethylene)-4-fluoro-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 145349-17-3
(2-fluoro-2-methylpropyl) trifluoromethanesulfonate

: 848949-86-0
ethyl-2-(diphenylmethyleneamino)-4-fluoro-4-methylpentanoate

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jo047918j

Reference yield:

: 98-88-4
benzoyl chloride

: 848949-86-0
ethyl-2-(diphenylmethyleneamino)-4-fluoro-4-methylpentanoate

: 848949-87-1
2-benzoylamino-4-fluoro-4-methyl-pentanoic acid

Guidance literature:: ethyl 2-((diphenylmethylene)amino)-4-fluoro-4-methylpentanoate; With hydrogenchloride; In water; at 20 ℃;

benzoyl chloride; With sodium hydrogencarbonate; at 20 ℃;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1021/jo047918j

Reference yield:

: 848949-86-0
ethyl-2-(diphenylmethyleneamino)-4-fluoro-4-methylpentanoate

: 848949-89-3
4-(2-fluoro-2-methyl-propyl)-2-phenyl-4H-oxazol-5-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / H₂O; various solvent(s) / 20 °C

1.2: NaHCO₃ / various solvent(s) / 20 °C

1.3: NaOH / tetrahydrofuran; H₂O; various solvent(s) / 20 °C

2.1: EDCI / CH₂Cl₂ / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; 1.2: Schotten-Baumman rection;
DOI:10.1021/jo047918j