Technology Process of 2-(3',5'-dimethoxyanilino)nicotinic acid
There total 1 articles about 2-(3',5'-dimethoxyanilino)nicotinic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper; potassium carbonate;
In
N,N-dimethyl-formamide;
for 3.5h;
Heating;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 9.5 g / polyphosphoric acid / 3 h / 100 °C
2: 7 g / potassium hydroxide / acetone / 6.5 h / Heating
3: 1.54 g / 47percent hydrobromic acid / acetic acid / 4 h / Heating
4: 161 mg / anhydrous potassium carbonate, potassium iodide / dimethylformamide / 22 h / 70 °C
5: 36 mg / N,N-diethylaniline / 3 h / Heating
With
potassium hydroxide; PPA; hydrogen bromide; potassium carbonate; N,N-diethylaniline; potassium iodide;
In
acetic acid; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 9.5 g / polyphosphoric acid / 3 h / 100 °C
2: 7 g / potassium hydroxide / acetone / 6.5 h / Heating
3: 1.54 g / 47percent hydrobromic acid / acetic acid / 4 h / Heating
4: 161 mg / anhydrous potassium carbonate, potassium iodide / dimethylformamide / 22 h / 70 °C
5: 70 mg / N,N-diethylaniline / 3 h / Heating
With
potassium hydroxide; PPA; hydrogen bromide; potassium carbonate; N,N-diethylaniline; potassium iodide;
In
acetic acid; N,N-dimethyl-formamide; acetone;
