2-oxa-7-azaspiro[3.5]nonane acetate

Base Information

• Chemical Name: 2-oxa-7-azaspiro[3.5]nonane acetate
• CAS No.: 1313369-52-6
• Molecular Formula: C₂H₄O₂*C₇H₁₃NO
• Molecular Weight: 187.239
• Mol file: 1313369-52-6.mol

Synonyms:

Chemical Property of 2-oxa-7-azaspiro[3.5]nonane acetate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-Oxa-7-aza-spiro[3.5]nonaneaceticacidsalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-oxa-7-azaspiro[3.5]nonane acetate

There total 5 articles about 2-oxa-7-azaspiro[3.5]nonane acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxa-7-aza-spiro[3.5]nonane (241820-91-7) + acetic acid (64-19-7,77671-22-8) → 2-oxa-7-azaspiro[3,5]nonane acetic acid salt (1313369-52-6)

Guidance literature:

In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2011.04.054

Reference yield:

C15H19NO3 (1313369-55-9) → 2-oxa-7-azaspiro[3,5]nonane acetic acid salt (1313369-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2: dichloromethane / 0.25 h / 0 °C

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;

DOI:10.1016/j.tetlet.2011.04.054

Reference yield:

1-(tert-butyl) 4,4-diethyl piperidine-1,4,4-tricarboxylate (848070-26-8) → 2-oxa-7-azaspiro[3,5]nonane acetic acid salt (1313369-52-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium borohydride / tetrahydrofuran; toluene / 60 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / 0 °C

2.2: 1.5 h / 0 °C

2.3: 1.5 h / 0 - 60 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.2: 2 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

5.1: dichloromethane / 0.25 h / 0 °C

With lithium borohydride; n-butyllithium; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1016/j.tetlet.2011.04.054

upstream raw materials:

C₁₅H₁₉NO₃

2-oxa-7-aza-spiro[3.5]nonane

acetic acid

1-(tert-butyl) 4,4-diethyl piperidine-1,4,4-tricarboxylate